Rh-catalyzed asymmetric hydrogenation of α-aryl imino esters:: An efficient enantioselective synthesis of aryl glycine derivatives

被引：115
|
作者：
Shang, Gao [1 ]
Yang, Qin [1 ]
Zhang, Xumu [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 38期
关键词：
amino acids; asymmetric catalysis; enantioselectivity; hydrogenation; reduction;
D O I：
10.1002/anie.200601540
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) A highly enantioselective synthesis of aryl glycine derivatives from asymmetric hydrogenation was achieved by subjecting N-PMP-protected α-aryl imino esters to hydrogenation under Rh-bisphosphine catalysis (see scheme; PMP = para-methoxyphenyl, cod = cycloocta-1,5-diene). The PMP group could be easily removed for the preparation of enantiomerically pure aryl glycine derivatives. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6360 / 6362
页数：3
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