Phenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase

被引：15
作者：
Cipriani, Andreza [1 ]
de Sousa, Adrieli Luz [1 ]
Tenfen, Adrielli [1 ,2 ]
Siebert, Diogo Alexandre [3 ]
de Gasper, Andre Luis [1 ]
Vitali, Luciano [3 ]
Micke, Gustavo Amadeu [3 ]
Alberton, Michele Debiasi [1 ]
机构：
[1] Fundacao Univ Reg Blumenau FURB, Blumenau, Brazil
[2] Soc Educ Santa Catarina Unisociesc, Jaragua Do Sul, Brazil
[3] Univ Fed Santa Catarina UFSC, Programa Posgrad Quim, Florianopolis, SC, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2020年 / 36卷 / 04期
关键词：
Phenolic; antioxidant; acetylcholinesterase; alpha-glucosidase;
D O I：
10.1080/14786419.2020.1855640
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Eugenia involucrata DC. (Myrtaceae), popularly known as "cereja-do-Rio-Grande", is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), ethyl acetate (FEA) and butanol (FBu)) of leaves were assessed to determine the phenolic chemical composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7-O-rutinoside, mandelic acid, naringenin, luteolin-7-O-glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC50 = 44.19 mu g mL(-1), for FEA) and alpha-glucosidase (alpha-Glu) (best result: IC50 = 31.25 +/- 0.15 mu g mL(-1), for CHE). The observed antioxidant and inhibitory activity on the AchE and alpha-Glu is due to, at least in part, the presence of phenolic compounds in the samples.
引用
收藏
页码：1134 / 1137
页数：4
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