Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Patients with Liver Cirrhosis

被引：4

作者：

Chen, Wen-Chi ^{[1
,2
]}

Hung, Chih-Hsin ^{[3
,4
]}

Chen, Yao-Shen ^{[2
,5
]}

Cheng, Jin-Shiung ^{[1
]}

Lee, Susan Shin-Jung ^{[2
,5
]}

Tseng, Fan-Chen ^{[6
,7
]}

Cheng, Ming-Fang ^{[3
,4
,8
,9
,10
,11
]}

Wang, Jiun-Ling ^{[12
,13
]}

机构：

[1] Natl Yang Ming Univ, Kaohsiung Vet Gen Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] I Shou Univ, Dept Chem Engn, Kaohsiung 840, Taiwan

[4] I Shou Univ, Inst Biotechnol & Chem Engn, Kaohsiung 840, Taiwan

[5] Natl Yang Ming Univ, Kaohsiung Vet Gen Hosp, Dept Internal Med, Div Infect Dis, Taipei 112, Taiwan

[6] China Med Univ, Grad Inst Basic Med Sci, Taipei 112, Taiwan

[7] Natl Taipei Univ Nursing & Hlth Sci, Dept Nursing, Taipei 112, Taiwan

[8] Kaohsiung Vet Gen Hosp, Dept Pediat, Kaohsiung 813, Taiwan

[9] Sch Med, Kaohsiung 813, Taiwan

[10] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[11] Fooyin Univ, Dept Nursing, Kaohsiung 831, Taiwan

[12] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 704, Taiwan

[13] Natl Cheng Kung Univ, Dept Med, Tainan 704, Taiwan

来源：

PATHOGENS | 2021年 / 10卷 / 01期

关键词：

bacteremia cirrhosis; Escherichia coli; extended-spectrum beta-lactamase; sequence type 131;

D O I：

10.3390/pathogens10010037

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: This study aimed to investigate the frequency of sequence type (ST) 131 strains and outcome of cirrhotic patients with bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing Escherichia coli (ESBLEC) and non-extended-spectrum beta-lactamase-producing Escherichia coli (NESBLEC). Methods: The incidence of ST 131 strains, hospital stay, and 30-day re-admission/mortality were compared between 51 ESBLEC and 51 NESBLEC bacteremic patients with cirrhosis. Results: ST 131 strains were found in 35.3% of the ESBLEC group and 0% of the NESBLEC group (p < 0.001). Mean hospital stay was 26.5 days in the ESBLEC group and 17.1 days in the NESBLEC group (p = 0.006). Thirty-day re-admission rates were 11.8% in the ESBLEC group and 5.9% in the NESBLEC group (p = 0.5). ST 131 strains were associated with 30-day re-admission (odds ratio: 4.5, 95% confidence interval: 1.1-18.9). Thirty-day mortality rate was 31.4% in the ESBLEC group and 23.5% in the NESBLEC group (p = 0.4). Conclusion: In patients with cirrhosis, the ESBLEC BSIs group had a higher frequency of ST 131 strains and longer hospital stay than the NESBLEC BSIs group with similar 30-day re-admission/mortality. ST 131 strains were associated with 30-day re-admission.

引用

页码：1 / 13

页数：13

共 43 条

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