Dynamic helix interactions in transmembrane signaling

被引：103

作者：

Matthews, Erin E.

Zoonens, Manuela

Engelman, Donald M.

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

CELL | 2006年 / 127卷 / 03期

关键词：

D O I：

10.1016/j.cell.2006.10.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these examples. Such efforts suggest that some of the most interesting properties of transmembrane helix interactions may be the least amenable to study by current techniques.

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收藏

页码：447 / 450

页数：4

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