An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

被引：32

作者：

Liu, Guoliang ^{[3
]}

Qian, Jiarui ^{[1
]}

Hua, Jing ^{[4
]}

Cai, Feng ^{[5
]}

Li, Xia ^{[3
]}

Liu, Lei ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

[2] Shandong Univ, Sch Chem & Chem Engn, Educ Minist, Key Lab Colloid & Interface Chem, Jinan 250100, Peoples R China

[3] Shandong Univ, Sch Ocean, Weihai 264209, Peoples R China

[4] Guangxi Normal Univ, Minist Educ China, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[5] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250012, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 03期

基金：

美国国家科学基金会;

关键词：

C-H OXIDATION; TRANSITION-METAL; QUINOLINE-2,4-DICARBOXYLIC ACIDS; STRUCTURALLY DIVERSE; CONVENIENT SYNTHESIS; FUNCTIONALIZATION; ARYLATION; QUINOLINE; BONDS; CONSTRUCTION;

D O I：

10.1039/c5ob02216a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and economical K2S2O8-mediated oxidative cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins has been established, affording structurally diverse quinoline-2-carboxylates in good to high efficiency. The low cost, negligible toxicity, and ease of handling of K2S2O8 combined with the absence of hazardous byproducts and the easy workup consisting of simple filtration are attractive based on economic and environmental factors.

引用

页码：1147 / 1152

页数：6

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