The biology and therapeutic management of melanoma brain metastases

被引：19

作者：

Abate-Daga, Daniel ^{[1
]}

Ramello, Maria C. ^{[1
]}

Smalley, Inna ^{[2
]}

Forsyth, Peter A. ^{[3
]}

Smalley, Keiran S. M. ^{[2
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, 12902 Magnolia Dr, Tampa, FL USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Tumor Biol, 12902 Magnolia Dr, Tampa, FL 33612 USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Neurooncol, 12902 Magnolia Dr, Tampa, FL USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2018年 / 153卷

基金：

美国国家卫生研究院;

关键词：

Melanoma; Metastasis; Brain; BRAF; Immunotherapy; BREAST-CANCER CELLS; TUMOR-INFILTRATING LYMPHOCYTES; NERVOUS-SYSTEM METASTASES; INHIBITOR RESISTANCE; OPEN-LABEL; BARRIER PERMEABILITY; PI3K PATHWAY; LUNG-CANCER; STEM-CELLS; IN-VITRO;

D O I：

10.1016/j.bcp.2017.12.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The recent years have seen significant progress in the development of systemic therapies to treat patients with advanced melanoma. Use of these new treatment modalities, which include immune checkpoint inhibitors and small molecule BRAF inhibitors, lead to increased overall survival and better outcomes. Although revolutionary, these therapies are often less effective against melanoma brain metastases, and frequently the CNS is the major site of treatment failure. The development of brain metastases remains a serious complication of advanced melanoma that is associated with significant morbidity and mortality. New approaches to both prevent the development of brain metastases and treat established disease are urgently needed. In this review we will outline the mechanisms underlying the development of melanoma brain metastases and will discuss how new insights into metastasis biology are driving the development of new therapeutic strategies. Finally, we will describe the latest data from the ongoing clinical trials for patients with melanoma brain metastases. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：35 / 45

页数：11

共 114 条

[11] Patterns of Response and Progression in Patients With BRAF-Mutant Melanoma Metastatic to the Brain Who Were Treated With Dabrafenib [J].

Azer, Mary W. F. ;

Menzies, Alexander M. ;

Haydu, Lauren E. ;

Kefford, Richard F. ;

Long, Georgina V. .

CANCER, 2014, 120 (04) :530-536

[12] Predictive Factors for the Development of Brain Metastasis in Advanced Unresectable Metastatic Melanoma [J].

Bedikian, Agop Y. ;

Wei, Caimiao ;

Detry, Michelle ;

Kim, Kevin B. ;

Papadopoulos, Nicholas E. ;

Hwu, Wen-Jen ;

Homsi, Jade ;

Davies, Michael ;

McIntyre, Susan ;

Hwu, Patrick .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2011, 34 (06) :603-610

[13] Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases [J].

Berghoff, Anna S. ;

Fuchs, Elisabeth ;

Ricken, Gerda ;

Mlecnik, Bernhard ;

Bindea, Gabriela ;

Spanberger, Thomas ;

Hackl, Monika ;

Widhalm, Georg ;

Dieckmann, Karin ;

Prayer, Daniela ;

Bilocq, Amelie ;

Heinzl, Harald ;

Zielinski, Christoph ;

Bartsch, Rupert ;

Birner, Peter ;

Galon, Jerome ;

Preusser, Matthias .

ONCOIMMUNOLOGY, 2016, 5 (01)

[14] Molecular characterization of breast cancer CTCs associated with brain metastasis [J].

Boral, Debasish ;

Vishnoi, Monika ;

Liu, Haowen N. ;

Yin, Wei ;

Sprouse, Marc L. ;

Scamardo, Antonio ;

Hong, David S. ;

Tan, Tuan Z. ;

Thiery, Jean P. ;

Chang, Jenny C. ;

Marchetti, Dario .

NATURE COMMUNICATIONS, 2017, 8

[15] Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy [J].

Brown, Christine E. ;

Alizadeh, Darya ;

Starr, Renate ;

Weng, Lihong ;

Wagner, Jamie R. ;

Naranjo, Araceli ;

Ostberg, Julie R. ;

Blanchard, M. Suzette ;

Kilpatrick, Julie ;

Simpson, Jennifer ;

Kurien, Anita ;

Priceman, Saul J. ;

Wang, Xiuli ;

Harshbarger, Todd L. ;

D'Apuzzo, Massimo ;

Ressler, Julie A. ;

Jensen, Michael C. ;

Barish, Michael E. ;

Chen, Mike ;

Portnow, Jana ;

Forman, Stephen J. ;

Badie, Behnam .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (26) :2561-2569

[16] Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations [J].

Bucheit, Amanda D. ;

Chen, Guo ;

Siroy, Alan ;

Tetzlaff, Michael ;

Broaddus, Russell ;

Milton, Denai ;

Fox, Patricia ;

Bassett, Roland ;

Hwu, Patrick ;

Gershenwald, Jeffrey E. ;

Lazar, Alexander J. ;

Davies, Michael A. .

CLINICAL CANCER RESEARCH, 2014, 20 (21) :5527-5536

[17] Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively [J].

Chang, MY ;

Son, H ;

Lee, YS ;

Lee, SH .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 23 (03) :414-426

[18] Adaptation of energy metabolism in breast cancer brain metastases [J].

Chen, Emily I. ;

Hewel, Johannes ;

Krueger, Joseph S. ;

Tiraby, Claire ;

Weber, Martin R. ;

Kralli, Anastasia ;

Becker, Katja ;

Yates, John R., III ;

Felding-Habermann, Brunhilde .

CANCER RESEARCH, 2007, 67 (04) :1472-1486

[19] Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target [J].

Chen, Guo ;

Chakravarti, Nitin ;

Aardalen, Kimberly ;

Lazar, Alexander J. ;

Tetzlaff, Michael T. ;

Wubbenhorst, Bradley ;

Kim, Sang-Bae ;

Kopetz, Scott ;

Ledoux, Alicia A. ;

Gopal, Y. N. Vashisht ;

Pereira, Cristiano Goncalves ;

Deng, Wanleng ;

Lee, Ju-Seog ;

Nathanson, Katherine L. ;

Aldape, Kenneth D. ;

Prieto, Victor G. ;

Stuart, Darrin ;

Davies, Michael A. .

CLINICAL CANCER RESEARCH, 2014, 20 (21) :5537-5546

[20] Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain [J].

Chen, Jinyu ;

Lee, Ho-Jeong ;

Wu, Xuefeng ;

Huo, Lei ;

Kim, Sun-Jin ;

Xu, Lei ;

Wang, Yan ;

He, Junqing ;

Bollu, Lakshmi R. ;

Gao, Guang ;

Su, Fei ;

Briggs, James ;

Liu, Xiaojing ;

Melman, Tamar ;

Asara, John M. ;

Fidler, Isaiah J. ;

Cantley, Lewis C. ;

Locasale, Jason W. ;

Zhang Weihua .

CANCER RESEARCH, 2015, 75 (03) :554-565

← 1 2 3 4 5 6 7 8 9 10 →