Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata

被引：49

作者：

Tchuendem, MHK

Mbah, JA

Tsopmo, A

Ayafor, JF

Sterner, O

Okunjic, CC

Iwu, MM

Schuster, BM

机构：

[1] Lund Inst Technol, Div Organ Chem 2, S-22100 Lund, Sweden

[2] Univ Dschang, Fac Sci, Dept Chem, Dschang, Cameroon

[3] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA

来源：

PHYTOCHEMISTRY | 1999年 / 52卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Reneilmia cincinnata; Zingiberaceae; isodaucane; germacrene; eudesmane; flavonoid; antiplasmodial activity;

D O I：

10.1016/S0031-9422(99)00344-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids oplodiol, oplopanone, 5E,10(14)-germacradien-1 beta,4 beta-diol, 1(10)E,5E-germacradien-4 alpha-ol and eudesman-1,4,7-triol. A large amount of 5-hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquirernenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1095 / 1099

页数：5

共 16 条

[1] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].