Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis

被引：102
作者：
Bacellar, Olivia [1 ]
Faria, Daniela [2 ]
Nascimento, Marcia [1 ]
Cardoso, Thiago M. [1 ]
Gollob, Kenneth J. [3 ]
Dutra, Walderez O. [2 ]
Scott, Phillip [4 ]
Carvalho, Edgar M. [1 ]
机构：
[1] Univ Fed Bahia, Serv Imunol, Hosp Univ Prof Edgard Santos, BR-40110160 Salvador, BA, Brazil
[2] Univ Fed Minas Gerais, Dept Morfol, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil
[4] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 01期
关键词：
MUCOSAL LEISHMANIASIS; CELL-ACTIVATION; T-CELLS; RESPONSES; GENERATION; INFECTIONS; RECEPTOR; FAMILY;
D O I：
10.1086/599380
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r(2) = 0.86; P<.001). These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.
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收藏
页码：75 / 78
页数：4
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