Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: a case report of an elderly man

被引：6

作者：

Takahashi, Kenta ^{[1
]}

Tsuda, Masumi ^{[1
]}

Kanno, Hiromi ^{[1
]}

Murata, Junichi ^{[2
]}

Mahabir, Roshan ^{[1
]}

Ishida, Yusuke ^{[1
]}

Kimura, Taichi ^{[1
]}

Tanino, Mishie ^{[1
]}

Nishihara, Hiroshi ^{[3
]}

Nagashima, Kazuo ^{[1
,4
]}

Tanaka, Shinya ^{[1
,3
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Canc Pathol, Kita Ku, Sapporo, Hokkaido, Japan

[2] Sapporo Azabu Neurosurg Hosp, Dept Neurosurg, Higashi Ku, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Translat Pathol, Kita Ku, Sapporo, Hokkaido, Japan

[4] Sapporo Higashi Tokushukai Hosp, Dept Pathol, Higashi Ku, Sapporo, Hokkaido, Japan

来源：

BRAIN TUMOR PATHOLOGY | 2014年 / 31卷 / 02期

关键词：

Small cell glioblastoma; Anaplastic oligodendroglioma; IDH1; mutation; 1p/19q loss; PTEN alteration; EGFR AMPLIFICATION;

D O I：

10.1007/s10014-013-0158-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.

引用

页码：118 / 123

页数：6

共 16 条

[1]

Boström J, 1998, CANCER RES, V58, P29

[2] Small cell architecture - A histological equivalent of EGFR amplification in glioblastoma multiforme? [J].

Burger, PC ;

Pearl, DK ;

Aldape, K ;

Yates, AJ ;

Scheithauer, BW ;

Passe, SM ;

Jenkins, RB ;

James, CD .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2001, 60 (11) :1099-1104

[3] Medical progress: Brain tumors [J].

DeAngelis, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (02) :114-123

[4] Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas [J].

Fujisawa, H ;

Reis, RM ;

Nakamura, M ;

Colella, S ;

Yonekawa, Y ;

Kleihues, P ;

Ohgaki, H .

LABORATORY INVESTIGATION, 2000, 80 (01) :65-72

[5] Molecular stratification of diagnostically challenging high-grade gliomas composed of small cells:: The utility of fluorescence in situ hybridization [J].

Korshunov, A ;

Sycheva, R ;

Golanov, A .

CLINICAL CANCER RESEARCH, 2004, 10 (23) :7820-7826

[6] The 2007 WHO classification of tumours of the central nervous system (vol 114, pg 97, 2007) [J].

Louis, David N. ;

Ohgaki, Hiroko ;

Wiestler, Otmar D. ;

Cavenee, Webster K. ;

Burger, Peter C. ;

Jouvet, Anne ;

Scheithauer, Bernd W. ;

Kleihues, Paul .

ACTA NEUROPATHOLOGICA, 2007, 114 (05) :547-547

[7]

Louis DN., 2007, WHO CLASSIFICATION T

[8] Molecular pathogenesis of pediatric astrocytic tumors [J].

Nakamura, Mitsutoshi ;

Shimada, Keiji ;

Ishida, Eiwa ;

Higuchi, Tomonori ;

Nakase, Hiroyuki ;

Sakaki, Toshisuke ;

Konishi, Noboru .

NEURO-ONCOLOGY, 2007, 9 (02) :113-123

[9] Genetic pathways to glioblastoma:: A population-based study [J].

Ohgaki, H ;

Dessen, P ;

Jourde, B ;

Horstmann, S ;

Nishikawa, T ;

Di Patre, PL ;

Burkhard, C ;

Schüler, D ;

Probst-Hensch, NM ;

Maiorka, PC ;

Baeza, N ;

Pisani, P ;

Yonekawa, Y ;

Yasargil, MG ;

Lütolf, UM ;

Kleihues, P .

CANCER RESEARCH, 2004, 64 (19) :6892-6899

[10] Genetic profile of astrocytic and oligodendroglial gliomas [J].

Ohgaki, Hiroko ;

Kleihues, Paul .

BRAIN TUMOR PATHOLOGY, 2011, 28 (03) :177-183

← 1 2 →