One-step, facile synthesis of pyrazolopyridines and tetrahydropyrazolopyridines through disproportionation of initially formed pyrazolo Hantzsch dihydropyridine

被引：14

作者：

Liu, Chuanxiang ^{[1
]}

Li, Zhong ^{[1
]}

Zhao, Liwei ^{[1
]}

Shen, Li ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, POB 544, Shanghai 200237, Peoples R China

来源：

ARKIVOC | 2009年

基金：

国家高技术研究发展计划(863计划);

关键词：

Pyrazolopyridine; heterocycles; Hantzsch; disproportionation; SOLVENT-FREE CONDITIONS; TRANSFER HYDROGENATION; RECEPTOR ANTAGONISTS; REDUCTION; POTENT; CHEMISTRY; LIGANDS; ACIDS; SAR;

D O I：

10.3998/ark.5550190.0010.224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a single-step synthesis of pyrazolopyridines and hydropyrazolopyridines by condensation 3-carbonitrile-5-aminopyrazole (1) with seven substituted alpha,beta-unsaturated aldehydes in acid medium. Straightforward access to various pyrazolopyridines and hydropyrazolopyridines was achieved through disproportionation of initially formed pyrazolo Hantzsch dihydropyridines. All the pyrazolopyridines and hydropyrazolopyridines were well characterized by spectroscopic analyses.

引用

收藏

页码：258 / 268

页数：11

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