Peripheral neuropathy in cystic fibrosis: A prevalence study

被引:12
作者
Chakrabarty, Biswaroop [1 ]
Kabra, S. K. [1 ]
Gulati, Sheffali [1 ]
Toteja, G. S. [2 ]
Lodha, Rakesh [1 ]
Kabra, Madhulika [1 ]
Pandey, R. M. [3 ]
Srivastava, Achal [4 ]
机构
[1] All India Inst Med Sci, Dept Pediat, New Delhi 110029, India
[2] Indian Council Med Res, TB Assoc India, Minist Hlth & Family Welf, New Delhi 110001, India
[3] All India Inst Med Sci, Dept Biostat, New Delhi 110029, India
[4] All India Inst Med Sci, Dept Neurol, New Delhi 110029, India
关键词
Axonal; Cystic fibrosis; Micronutrients; Polyneuropathy; Sensory; VITAMIN-E-DEFICIENCY; ASSOCIATION; ADULTS;
D O I
10.1016/j.jcf.2013.01.005
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: Information on peripheral neuropathy in children with cystic fibrosis is scanty. The etiology can be multifactorial (micronutrient deficiency, chronic hypoxia, impaired glucose tolerance, immunological, vasculopathic, critical illness). Methods: Forty five cystic fibrosis children aged 1-18 years on vitamin E supplementation for at least 6 months underwent detailed neurological examination, serum vitamin E, vitamin B12, folate, copper levels and detailed nerve conduction studies. Results: The mean age of the study population was 8.35 years (+/- 4.9 years) with 62.2% being males. Overall 22 out of 45 (48.88%,CI: 33.7-64.2) had electrophysiological evidence of peripheral neuropathy which was predominantly axonal (86.4%), sensory (50%), and polyneuropathy (95.45%). There was no significant association between status of serum micronutrients and electrophysiological evidence of peripheral neuropathy. Conclusion: Patients with cystic fibrosis have electrophysiological evidence of peripheral neuropathy (predominantly axonal, sensory and polyneuropathy). There is significant association of higher chronological age with occurrence of peripheral neuropathy. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:754 / 760
页数:7
相关论文
共 27 条
[1]  
Boat TF, 2008, NELSON TXB PEDIAT, V2
[2]   SYMPTOMATIC VITAMIN-E-DEFICIENCY IN CYSTIC-FIBROSIS [J].
BYE, AME ;
MULLER, DPR ;
WILSON, J ;
WRIGHT, VM ;
MEARNS, MB .
ARCHIVES OF DISEASE IN CHILDHOOD, 1985, 60 (02) :162-164
[3]   EFFECT OF VITAMIN-E-DEFICIENCY ON NEUROLOGIC FUNCTION IN PATIENTS WITH CYSTIC-FIBROSIS [J].
CYNAMON, HA ;
MILOV, DE ;
VALENSTEIN, E ;
WAGNER, M .
JOURNAL OF PEDIATRICS, 1988, 113 (04) :637-640
[4]   Cystic fibrosis mortality and survival in the UK: 1947-2003 [J].
Dodge, J. A. ;
Lewis, P. A. ;
Stanton, M. ;
Wilsher, J. .
EUROPEAN RESPIRATORY JOURNAL, 2007, 29 (03) :522-526
[5]   Peripheral Nerve Dysfunction in Patients With Cystic Fibrosis [J].
El-Salem, Khalid ;
Aburahma, Samah ;
Rawashdeh, Mohammad .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2010, 27 (03) :216-218
[6]  
ELIAS E, 1981, LANCET, V2, P1319
[7]   Distal symmetric polyneuropathy: A definition for clinical research - Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation [J].
England, JD ;
Gronseth, GS ;
Franklin, G ;
Miller, RG ;
Asbury, AK ;
Carter, GT ;
Cohen, JA ;
Fisher, MA ;
Howard, JF ;
Kinsella, LJ ;
Latov, N ;
Lewis, RA ;
Low, PA ;
Sumner, AJ .
NEUROLOGY, 2005, 64 (02) :199-207
[8]   OCCURRENCE AND EFFECTS OF HUMAN VITAMIN-E-DEFICIENCY - STUDY IN PATIENTS WITH CYSTIC-FIBROSIS [J].
FARRELL, PM ;
BIERI, JG ;
FRATANTONI, JF ;
WOOD, RE ;
DISANTAGNESE, PA .
JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (01) :233-241
[9]   EVALUATION OF VITAMIN-E-DEFICIENCY IN CHILDREN WITH LUNG-DISEASE [J].
FARRELL, PM ;
MISCHLER, EH ;
GUTCHER, GR .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1982, 393 (SEP) :96-108
[10]  
Frank Y, 2006, PEDIAT NEUROLOGY PRI, V2