Design, synthesis and biological evaluation of a novel Cu2+-selective fluorescence sensor for bio-detection and chelation

被引：19

作者：

Gao, Yu ^{[1
]}

Li, Yazhen ^{[1
]}

Yang, Xiping ^{[1
]}

He, Fangfei ^{[1
]}

Huang, Jiamei ^{[1
]}

Jiang, Minghong ^{[1
]}

Zhou, Zaihui ^{[1
]}

Chen, Haijun ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 98期

基金：

中国国家自然科学基金;

关键词：

LIVING CELLS; COPPER; CU2+; CHEMOSENSOR; THERAPY; DISEASE; WATER; NANOTHERANOSTICS; CANCER; RATS;

D O I：

10.1039/c5ra12620g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel fluorescence sensor was designed and synthesized for detecting Cu2+ with high sensitivity and selectivity. The sensor showed a large red-shift in UV-vis spectra and obvious decline of fluorescent intensity in fluorescence emission spectra upon the addition of Cu2+. Bio-imaging studies and flow cytometric analysis revealed that this sensor was cell-permeable and could be used for detection of changes of intracellular Cu2+, suggesting the suitability of this sensor for biological application. Cell cytotoxicity studies demonstrated it was capable of chelating excess Cu2+ in vitro to modulate the biological functions of Cu2+ with low cytotoxicity. Therefore, this compound could be a promising fluorescent sensor combining the abilities of either detection or modulation of the biological function of Cu2+ in biological conditions.

引用

页码：80110 / 80117

页数：8

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