Amine bridges grafted mesoporous silica, as a prolonged/controlled drug release system for the enhanced therapeutic effect of short life drugs

被引：26

作者：

Rehman, Fozia ^{[1
,2
]}

Ahmed, Khalid ^{[1
]}

Airoldi, Claudio ^{[1
]}

Gaisford, Simon ^{[3
]}

Buanz, Asma ^{[3
]}

Rahim, Abdur ^{[2
]}

Muhammad, Nawshad ^{[2
]}

Volpe, Pedro L. O. ^{[1
]}

机构：

[1] Univ Estadual Campinas, UNICAMP, Inst Chem, POB 6154, BR-13084971 Campinas, SP, Brazil

[2] COMSATS Inst Informat Technol, IRCBM, Lahore, Pakistan

[3] UCL, UCL Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 72卷

关键词：

Mesoporous silica; Surface modification; Ibuprofen and controlled drug release; AQUEOUS-SOLUTION; NANOPARTICLES; IBUPROFEN; DELIVERY; SURFACE; SBA-15; PROPERTY; REMOVAL; SPHERES; CELLS;

D O I：

10.1016/j.msec.2016.11.040

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Hybrid mesoporous silica SBA-15, with surface incorporated cross-linked long hydrophobic organic bridges was synthesized using stepwise synthesis. The synthesized materials were characterized by elemental analysis, infrared spectroscopy, nuclear magnetic resonance spectroscopy, nitrogen adsorption, X-rays diffraction, thermogravimetry and scanning and transmission electron microscopy. The functionalized material showed highly ordered mesoporous network with a surface area of 629.0 m(2) g(-1). The incorporation of long hydrophobic amine chains on silica surface resulted in high drug loading capacity (21% Mass/Mass) and prolonged release of ibuprofen up till 75.5 h. The preliminary investigations suggests that the synthesized materials could be proposed as controlled release devices to prolong the therapeutic effect of short life drugs such as ibuprofen to increase its efficacy and to reduce frequent dosage. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：34 / 41

页数：8

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