Recent Advances in Cell Membrane-Derived Biomimetic Nanotechnology for Cancer Immunotherapy

被引：115

作者：

Raza, Faisal ^{[1
]}

Zafar, Hajra ^{[1
]}

Zhang, Shulei ^{[1
]}

Kamal, Zul ^{[1
,2
]}

Su, Jing ^{[1
]}

Yuan, Wei-En ^{[1
]}

Qiu, Mingfeng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Shaheed Benazir Bhutto Univ, Dept Pharm, Khyber Pakhtunkhwa 18000, Pakistan

来源：

ADVANCED HEALTHCARE MATERIALS | 2021年 / 10卷 / 06期

基金：

上海市自然科学基金;

关键词：

biomimetic nanoparticles; cancer immunotherapy; cell membranes; effective drug delivery; nanotechnology; IMMUNE CHECKPOINT BLOCKADE; ANTIGEN-PRESENTING CELLS; RED-BLOOD-CELLS; ERYTHROCYTE-MEMBRANE; DRUG-DELIVERY; MULTIFUNCTIONAL NANOPARTICLES; THERAPEUTIC VACCINES; COATED NANOPARTICLES; STRATEGIES; CARRIERS;

D O I：

10.1002/adhm.202002081

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Immunotherapy will significantly impact the standard of care in cancer treatment. Recent advances in nanotechnology can improve the efficacy of cancer immunotherapy. However, concerns regarding efficiency of cancer nanomedicine, complex tumor microenvironment, patient heterogeneity, and systemic immunotoxicity drive interest in more novel approaches to be developed. For this purpose, biomimetic nanoparticles are developed to make innovative changes in the delivery and biodistribution of immunotherapeutics. Biomimetic nanoparticles have several advantages that can advance the clinical efficacy of cancer immunotherapy. Thus there is a greater push toward the utilization of biomimetic nanotechnology for developing effective cancer immunotherapeutics that demonstrate increased specificity and potency. The recent works and state-of-the-art strategies for anti-tumor immunotherapeutics are highlighted here, and particular emphasis has been given to the applications of cell-derived biomimetic nanotechnology for cancer immunotherapy.

引用

页数：27

共 136 条

[11] Oncology Meets Immunology: The Cancer-Immunity Cycle [J].