Estimating the prevalence of myelodysplastic syndromes in patients with unexplained cytopenias: A retrospective study of 322 bone marrows

被引：46
作者：
Buckstein, Rena [1 ]
Jang, Karen [2 ]
Friedlich, Jessica [3 ]
Zhang, Liying [4 ]
Reis, Marciano [5 ]
Chesney, Alden [5 ]
Wells, Richard A.
机构：
[1] Sunnybrook Hlth Sci Ctr, Dept Hematol Oncol, Odette Canc Ctr, MDS Res Program, Toronto, ON M4N 3M5, Canada
[2] Univ Toronto, Dept Med, Toronto, ON, Canada
[3] Univ Western Ontario, London, ON, Canada
[4] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Dept Clin Trials, Toronto, ON M4N 3M5, Canada
[5] Sunnybrook Hlth Sci Ctr, Dept Clin Pathol, Toronto, ON M4N 3M5, Canada
来源：
LEUKEMIA RESEARCH | 2009年 / 33卷 / 10期
关键词：
Myelodysplastic syndromes (MDS); Prevalence; Bone marrow; Incidence; Anemia in the elderly; HEMOGLOBIN CONCENTRATION; SCORING SYSTEM; OLDER PERSONS; UNITED-STATES; ANEMIA; ERYTHROPOIETIN; IMPACT; WOMEN; RISK; LDH;
D O I：
10.1016/j.leukres.2009.02.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although unexplained anemia is common in the elderly, the prevalence of MDS is poorly defined. We reviewed 2267 bone marrows reviewed at our center between the years 2002 and 2005. Of these, 322 met our criteria for inclusion (14%). Seventy-three patients (22.6%) had a confirmed diagnosis of MDS and 32 (9.9%) had suspected MDS. Confirmed or suspected MDS was more likely in patients aged >65 (31.5% and 11%, respectively). Age, MCV, LDH and RDW were independently predictive of MDS. Extrapolation of our findings to the elderly anemic individuals in the community suggests MDS prevalence may be higher than previously postulated. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1313 / 1318
页数：6
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