A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'-phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors.

被引：28

作者：

Branalt, J

Kvarnstrom, I

Classon, B

Samuelsson, B

Nillroth, U

Danielson, UH

Karlen, A

Hallberg, A

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

[2] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

[3] UNIV UPPSALA,DEPT BIOCHEM,BMC,S-75123 UPPSALA,SWEDEN

[4] UNIV UPPSALA,DEPT ORGAN PHARMACEUT CHEM,BMC,S-75123 UPPSALA,SWEDEN

[5] AB HASSLE,S-43183 MOLNDAL,SWEDEN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(97)00662-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new short route to epoxide 6b, a pivotal intermediate for the preparation of hydroxyethylamine dipeptide isosteres has been developed. Opening of the epoxide by anthranilic acid, followed by extensions in the PZ/P3-region gave the target compounds which were evaluated as HIV-1 protease inhibitors. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：3483 / 3486

页数：4

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