The protective effect of Mucuna pruriens seeds against snake venom poisoning

被引：37
作者：
Tan, Nget Hong [1 ]
Fung, Shin Yee
Sim, Si Mui
Marinello, Enrico [2 ]
Guerranti, Roberto [2 ]
Aguiyi, John C. [3 ]
机构：
[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia
[2] Univ Siena, I-53100 Siena, Italy
[3] Univ Jos, Jos, Nigeria
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2009年 / 123卷 / 02期
关键词：
Mucuna pruriens seeds; Anti-snake venoms; Antivenom; ECHIS-CARINATUS VENOM; EXTRACT;
D O I：
10.1016/j.jep.2009.03.025
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ethnopharmacological relevance: The seed, leaf and root of Mucuna pruriens have been used in traditional medicine for treatments of various diseases. In Nigeria, the seed is used as oral prophylactics for snakebite. Aim of the study: To study the protective effects of Mucuna pruriens seed extract against the lethalities of various snake venoms. Materials and methods: Rats were pre-treated with Mucuna pruriens seed extract and challenged with various snake venoms. The effectiveness of anti-Mucuna pruriens (anti-MPE) antibody to neutralize the lethalities of snake venoms was investigated by in vitro neutralization. Results: In rats, MPE pre-treatment conferred effective protection against lethality of Naja sputatrix venom and moderate protection against Calloselasma rhodostoma venom. Indirect ELISA and immunoblotting studies showed that there were extensive cross-reactions between anti-MPE IgG and venoms from many different genera of poisonous snakes, suggesting the involvement of immunological neutralization in the protective effect of MPE pre-treatment against snake venom poisoning. In vitro neutralization experiments showed that the anti-MPE antibodies effectively neutralized the lethalities of Asiatic cobra (Naja)venoms, but were not very effective against other venoms tested. Conclusions: The anti-MPE antibodies could be used in the antiserum therapy of Asiatic cobra (Naja) bites. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：356 / 358
页数：3
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