Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase-B inhibitors

被引：20
|
作者：
Sudevan, Sachithra T. [1 ]
Rangarajan, T. M. [2 ]
Al-Sehemi, Abdullah G. [3 ,4 ]
Nair, Aathira S. [1 ]
Koyiparambath, Vishal P. [1 ]
Mathew, Bijo [1 ]
机构：
[1] Amrita Vishwa Vidyapeetham, Amrita Sch Pharm, Dept Pharmaceut Chem, AIMS Hlth Sci Campus, Kochi 682041, Kerala, India
[2] Univ Delhi, Dept Chem, Sri Venketeswara Coll, New Delhi, India
[3] King Khalid Univ, Res Ctr Adv Mat Sci, Abha, Saudi Arabia
[4] King Khalid Univ, Dept Chem, Abha 61413, Saudi Arabia
来源：
ARCHIV DER PHARMAZIE | 2022年 / 355卷 / 08期
关键词：
benzyloxy pharmacophore; MAO-A; MAO-B; neurological disorders; structure-activity relationships; 2H-CHROMEN-2-ONE DERIVATIVES; BIOLOGICAL EVALUATION; CHROMONE DERIVATIVES; COUMARIN DERIVATIVES; PLATELET SEROTONIN; HIGHLY POTENT; IN-VIVO; ANALOGS; PF9601N; SAFINAMIDE;
D O I：
10.1002/ardp.202200084
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The conceptual layout of monoamine oxidase (MAO) inhibitors has been modified to explore their potential biological application in the case of neurological disorders for the time being. The current review article is an effort to display the summation of innovative conceptual prospects of MAO inhibitors and their intriguing chemistry and bioactivity. Based on this scenario, we emphasize the pivotal role of the benzyloxy moiety attached to scaffolds like oxadiazolones, indolalkylamines, safinamide, caffeine, benzofurans, alpha-tetralones, beta-nitrostyrene, benzoquinones, coumarins, indoles, chromones, and chromanone analogs, while acting as an MAO inhibitor.
引用
收藏
页数：40
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