Ewing's Sarcoma

被引：207

作者：

Riggi, Nicolo ^{[1
,2
]}

Suva, Mario L. ^{[3
,4
,5
,6
]}

Stamenkovic, Ivan ^{[1
,2
]}

机构：

[1] Univ Lausanne, Inst Pathol, Fac Biol & Med, Lausanne, Switzerland

[2] CHU Vaudois, CH-1011 Lausanne, Switzerland

[3] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Broad Inst Harvard Univ & Massachusetts Inst Tech, Cambridge, MA 02138 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2021年 / 384卷 / 02期

关键词：

FACTOR-I RECEPTOR; TRANSCRIPTION FACTOR; MONOCLONAL-ANTIBODY; PROGNOSTIC-FACTORS; GENOMIC LANDSCAPE; PROTEIN EWS-FLI1; GENE FUSION; TUMORS; GROWTH; EWS;

D O I：

10.1056/NEJMra2028910

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily affects children and young adults. A t(11;22) translocation is noted in 85 to 90% of cases. Management includes surgery, radiotherapy, and chemotherapy. The 5-year survival is about 70%.

引用

页码：154 / 164

页数：11

共 90 条

[1] RGG-boxes of the EWS oncoprotein repress a range of transcriptional activation domains [J].

Alex, D ;

Lee, KAW .

NUCLEIC ACIDS RESEARCH, 2005, 33 (04) :1323-1331

[2] Sarcomas With CIC-rearrangements Are a Distinct Pathologic Entity With Aggressive Outcome: A Clinicopathologic and Molecular Study of 115 Cases [J].

Antonescu, Cristina R. ;

Owosho, Adepitan A. ;

Zhang, Lei ;

Chen, Sonja ;

Deniz, Kemal ;

Huryn, Joseph M. ;

Kao, Yu-Chien ;

Huang, Shih-Chiang ;

Singer, Samuel ;

Tap, William ;

Schaefer, Inga-Marie ;

Fletcher, Christopher D. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (07) :941-949

[3] Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution [J].

Aynaud, Marie-Ming ;

Mirabeau, Olivier ;

Gruel, Nadege ;

Grossetete, Sandrine ;

Boeva, Valentina ;

Durand, Simon ;

Surdez, Didier ;

Saulnier, Olivier ;

Zaidi, Sakina ;

Gribkova, Svetlana ;

Fouche, Aziz ;

Kairov, Ulykbek ;

Raynal, Virginie ;

Tirode, Franck ;

Gruenewald, Thomas G. P. ;

Bohec, Mylene ;

Baulande, Sylvain ;

Janoueix-Lerosey, Isabelle ;

Vert, Jean-Philippe ;

Barillot, Emmanuel ;

Delattre, Olivier ;

Zinovyev, Andrei .

CELL REPORTS, 2020, 30 (06) :1767-+

[4] EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations [J].

Beck, Robert ;

Monument, Michael J. ;

Watkins, W. Scott ;

Smith, Richard ;

Boucher, Kenneth M. ;

Schiffman, Joshua D. ;

Jorde, Lynn B. ;

Randall, R. Lor ;

Lessnick, Stephen L. .

CANCER GENETICS, 2012, 205 (06) :304-312

[5] Evaluation of Outcome and Prognostic Factors in Extraosseous Ewing Sarcoma [J].

Biswas, Bivas ;

Shukla, N. K. ;

Deo, S. V. S. ;

Agarwala, Sandeep ;

Sharma, D. N. ;

Vishnubhatla, Sreenivas ;

Bakhshi, Sameer .

PEDIATRIC BLOOD & CANCER, 2014, 61 (11) :1925-1931

[6] Molecular Signals of Epigenetic States [J].

Bonasio, Roberto ;

Tu, Shengjiang ;

Reinberg, Danny .

SCIENCE, 2010, 330 (6004) :612-616

[7] Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain [J].

Boulay, Gaylor ;

Sandoval, Gabriel J. ;

Riggi, Nicolo ;

Iyer, Sowmya ;

Buisson, Remi ;

Naigles, Beverly ;

Awad, Mary E. ;

Rengarajan, Shruthi ;

Volorio, Angela ;

McBride, Matthew J. ;

Broye, Liliane C. ;

Zou, Lee ;

Stamenkovic, Ivan ;

Kadoch, Cigall ;

Rivera, Miguel N. .

CELL, 2017, 171 (01) :163-+

[8]

Brennan B, 2020, J CLIN ONCOL, V38

[9] PARP-1 Inhibition as a Targeted Strategy to Treat Ewing's Sarcoma [J].

Brenner, J. Chad ;

Feng, Felix Y. ;

Han, Sumin ;

Patel, Sonam ;

Goyal, Siddharth V. ;

Bou-Maroun, Laura M. ;

Liu, Meilan ;

Lonigro, Robert ;

Prensner, John R. ;

Tomlins, Scott A. ;

Chinnaiyan, Arul M. .

CANCER RESEARCH, 2012, 72 (07) :1608-1613

[10] Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer [J].

Brenner, J. Chad ;

Ateeq, Bushra ;

Li, Yong ;

Yocum, Anastasia K. ;

Cao, Qi ;

Asangani, Irfan A. ;

Patel, Sonam ;

Wang, Xiaoju ;

Liang, Hallie ;

Yu, Jindan ;

Palanisamy, Nallasivam ;

Siddiqui, Javed ;

Yan, Wei ;

Cao, Xuhong ;

Mehra, Rohit ;

Sabolch, Aaron ;

Basrur, Venkatesha ;

Lonigro, Robert J. ;

Yang, Jun ;

Tomlins, Scott A. ;

Maher, Christopher A. ;

Elenitoba-Johnson, Kojo S. J. ;

Hussain, Maha ;

Navone, Nora M. ;

Pienta, Kenneth J. ;

Varambally, Sooryanarayana ;

Feng, Felix Y. ;

Chinnaiyan, Arul M. .

CANCER CELL, 2011, 19 (05) :664-678

← 1 2 3 4 5 6 7 8 9 →