Human metapneumovirus pneumonia in patients with hematological malignancies

被引：28

作者：

Godet, Cendrine ^{[1
]}

Le Goff, Jerome ^{[2
]}

Beby-Defaux, Agnes ^{[3
]}

Robin, Marie ^{[4
]}

Raffoux, Emmanuel ^{[5
]}

Arnulf, Bertrand ^{[6
]}

Roblot, France ^{[1
]}

Frat, Jean Pierre ^{[7
]}

Maillard, Natacha ^{[8
]}

Tazi, Abdellatif ^{[9
,10
]}

Bergeron, Anne ^{[9
,10
]}

机构：

[1] CHU Poitiers, Serv Malad Infect & Med Interne, Poitiers, France

[2] Univ Paris Diderot, Hop St Louis, AP HP, Microbiol Lab,Sorbonne Paris Cite, Paris, France

[3] Univ Poitiers, CHU Poitiers, Serv Virol, Poitiers, France

[4] Univ Paris Diderot, Hop St Louis, AP HP, Serv Hematol Greffe, Paris, France

[5] Univ Paris Diderot, Hop St Louis, AP HP, Paris, France

[6] Univ Paris Diderot, Hop St Louis, AP HP, Serv Immunohematol, Paris, France

[7] CHU Poitiers, Serv Reanimat Med, Poitiers, France

[8] CHU Poitiers, Serv Hematol, Poitiers, France

[9] Univ Paris Diderot, Sorbonne Paris Cite, Biostat & Clin Epidemiol Res Team ECSTRA, INSERM,UMR 1153, Paris, France

[10] Hop St Louis, AP HP, Serv Pneumol, F-75010 Paris, France

来源：

JOURNAL OF CLINICAL VIROLOGY | 2014年 / 61卷 / 04期

关键词：

Metapneumovirus; Emerging virus; Respiratory infection; Immunocompromised; Hematological patients; RESPIRATORY-TRACT INFECTIONS; SYNCYTIAL VIRUS; RECIPIENTS; PCR;

D O I：

10.1016/j.jcv.2014.08.019

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Human metapneumovirus (HMPV) has recently emerged as a cause of respiratory infections in hematological patients. Clinical data are lacking to guide the management of HMPV pneumonias. Objectives: To characterize the clinical and radiographic presentation and outcome of HMPV pneumonias diagnosed in hematological patients. Study design: We screened the patients with a positive HMPV respiratory test in two French teaching hospitals between 2007 and 2011. Among them, the medical charts from the hematological patients who presented with HMPV pneumonia were reviewed. Results: Among the 54 patients with several underlying hematological conditions who were positive for HMPV, we found 13 cases of HMPV pneumonias. HMPV could be the cause of pneumonia as a single pathogen without associated upper respiratory infection. Centrilobular nodules were constant on lung computed tomography scans. No patients died despite the absence of administration of antiviral treatments. Conclusions: Our data provide further insights in the diagnosis and management of HMPV pneumonias in this setting. (C) 2014 Published by Elsevier B.V.

引用

页码：593 / 596

页数：4

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