Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man

被引:263
|
作者
Owen, AM
Morris, RG
Sahakian, BJ
Polkey, CE
Robbins, TW
机构
[1] UNIV CAMBRIDGE, DEPT EXPT PSYCHOL, CAMBRIDGE CB2 1TN, ENGLAND
[2] UNIV CAMBRIDGE, DEPT PSYCHIAT, CAMBRIDGE CB2 1TN, ENGLAND
[3] UNIV LONDON, INST PSYCHIAT, NEUROPSYCHOL UNIT, LONDON SE5 8AF, ENGLAND
[4] MAUDSLEY HOSP & INST PSYCHIAT, NEUROSURG UNIT, LONDON SE5 8AZ, ENGLAND
基金
英国惠康基金;
关键词
working memory; frontal cortex; temporal cortex; amygdala; executive functions;
D O I
10.1093/brain/119.5.1597
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Thirty-two neurosurgical patients with unilateral or bilateral frontal lobe excisions, 41 patients with unilateral temporal lobe lesions and 19 patients Who had undergone unilateral amygdalo-hippocampectomy were compared with matched controls on a computerized test of spatial working memory. A significant deficit was observed in the frontal lobe group, even at the least challenging level of task difficulty and this impairment was found to relate to the inefficient use of a particular searching strategy shown to improve performance on this task. In contrast deficits in the temporal lobe group and the amygdalo-hippocampectomy group were only observed Pt the most difficult level of the task and in neither group could the deficit be related to the inefficient use of any particular searching strategy. In a follow-tip study, the three patient groups were compared on analogous computerized tests of visual-and verbal working memory. No deficits were observed in the frontal lobe group. By comparison, both the temporal lobe patients and the amygdalo-hippocampectomy group were significantly impaired in the visual working memory condition but not in the verbal working memory condition. These deficits were clearly evident at all levels of task difficulty and were not related to any particular searching strategy The data are discussed in terms of the relative contributions of 'executive' and 'mnemonic' mechanisms to the contrasting, material dependent deficits observed in the frontal and temporal lobe groups.
引用
收藏
页码:1597 / 1615
页数:19
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