Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

被引：45
|
作者：
Sassatelli, Mathieu
Debiton, Eric
Aboab, Bettina
Prudhomme, Michelle
Moreau, Pascale
机构：
[1] Univ Clermont Ferrand, Lab SEESIB, UMR 6504, CNRS, F-63177 Aubiere, France
[2] Univ Auvergne, Lab Pharmacognosie Biotechnol UMR 484, INSERM, Ctr Jean Perrin, F-63005 Clermont Ferrand, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 06期
关键词：
indolin-2-ones; amino acids; antiproliferative activities;
D O I：
10.1016/j.ejmech.2006.03.021
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Ben, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture). (c) 2006 Elsevier SAS. All rights reserved.
引用
收藏
页码：709 / 716
页数：8
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