Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

被引：45
|
作者：
Sassatelli, Mathieu
Debiton, Eric
Aboab, Bettina
Prudhomme, Michelle
Moreau, Pascale
机构：
[1] Univ Clermont Ferrand, Lab SEESIB, UMR 6504, CNRS, F-63177 Aubiere, France
[2] Univ Auvergne, Lab Pharmacognosie Biotechnol UMR 484, INSERM, Ctr Jean Perrin, F-63005 Clermont Ferrand, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 06期
关键词：
indolin-2-ones; amino acids; antiproliferative activities;
D O I：
10.1016/j.ejmech.2006.03.021
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Ben, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture). (c) 2006 Elsevier SAS. All rights reserved.
引用
收藏
页码：709 / 716
页数：8
相关论文
共 50 条
  • [21] Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils
    Chu, Wenhua
    Zhou, Dong
    Gaba, Vrinda
    Liu, Jialu
    Li, Shihong
    Peng, Xin
    Xu, Jinbin
    Dhavale, Dhruva
    Bagchi, Devika P.
    d'Avignon, Andre
    Shakerdge, Naomi B.
    Bacskai, Brian J.
    Tu, Zhude
    Kotzbauer, Paul T.
    Mach, Robert H.
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (15) : 6002 - 6017
  • [22] 3-(Phenylimino)indolin-2-one
    Al Subari, Abdusalam
    Bouhfid, Rachid
    Zouihri, Hafid
    Essassi, El Mokhtar
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O453 - U3325
  • [23] Efficient synthesis of new oxindol-based heterocyclic entities via indolin-2-one derivatives
    Zaky, Howida T.
    Mohamed, Mansoura I.
    Kandile, Nadia G.
    ARABIAN JOURNAL OF CHEMISTRY, 2014, 7 (05) : 630 - 638
  • [24] 3-(Diphenylmethylidene)indolin-2-one
    Yuan, Maosen
    Wang, Qi
    Zhang, Shujun
    Gao, Peng
    Wang, Junru
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2098 - U1069
  • [25] Synthesis and bio-evaluation of quaternary centered 3-hydroxy-3-(trifluoromethyl)indolin-2-one derivatives for anticancer and antimicrobial activities
    Raktani Bikshapathi
    Parvathaneni Sai Prathima
    B. Yashwanth
    R. Pamanji
    G. Jagadeeshkumar
    R. Maheshwari
    J. Venkateswara Rao
    U. S. N. Murty
    V. Jayathirtha Rao
    Monatshefte für Chemie - Chemical Monthly, 2017, 148 : 757 - 764
  • [26] A clean synthesis of 3,3-bis(5-amino-1H-pyrazol-4-yl)indolin-2-one derivatives
    Ahadi, Somayeh
    Shakibaei, Ghazaleh Imani
    Mirzaei, Peiman
    Bazgir, Ayoob
    HETEROCYCLES, 2008, 75 (09) : 2293 - 2299
  • [27] Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties
    Luan, Tian
    Quan, Zheshan
    Fang, Yingquan
    Yang, Hongjing
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (02) : 440 - 446
  • [28] Synthesis and bio-evaluation of quaternary centered 3-hydroxy-3-(trifluoromethyl)indolin-2-one derivatives for anticancer and antimicrobial activities
    Bikshapathi, Raktani
    Prathima, Parvathaneni Sai
    Yashwanth, B.
    Pamanji, R.
    Jagadeeshkumar, G.
    Maheshwari, R.
    Rao, J. Venkateswara
    Murty, U. S. N.
    Rao, V. Jayathirtha
    MONATSHEFTE FUR CHEMIE, 2017, 148 (04): : 757 - 764
  • [29] Synthesis and in vitro antitumor activity of 1-(3-dimethylamino)propyl indolin-2-one derivatives
    Lv, Kai
    Wang, Li-Li
    Zhou, Xin-Bo
    Liu, Ming-Liang
    Liu, Hong-Ying
    Zheng, Zhi-Bing
    Li, Song
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (04) : 1723 - 1729
  • [30] Synthesis and receptor binding assay of indolin-2-one derivatives as dopamine D4 receptor ligands
    Li Gu-Cai
    Zhang Bian-Ling
    Xia Jiao-Yun
    Fang Zheng-Jun
    PHARMAZIE, 2015, 70 (08): : 511 - 514
12345