Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging

被引：32
作者：
Almer, Gunter [1 ]
Mangge, Harald [1 ,4 ]
Zimmer, Andreas [2 ,4 ]
Prassl, Ruth [3 ,4 ]
机构：
[1] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Res Unit Lifestyle & Inflammation Associated Risk, A-8010 Graz, Austria
[2] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Epartment Pharmaceut Technol, Graz, Austria
[3] Med Univ Graz, Inst Biophys, A-8010 Graz, Austria
[4] BioTechMed Graz, Graz, Austria
来源：
CURRENT MEDICINAL CHEMISTRY | 2015年 / 22卷 / 31期
基金：
奥地利科学基金会;
关键词：
Apolipoproteins; artificial lipoproteins; high density lipoproteins; lipoprotein related nanoparticles; low density lipoproteins; recombinant lipoproteins; reconstituted lipoproteins; synthetic lipoproteins; LOW-DENSITY-LIPOPROTEIN; CONTRAST AGENT; A-I; LABELED LDL; ATHEROSCLEROTIC PLAQUES; FLUORESCENT-PROBES; ANTITUMORAL DRUGS; RECONSTITUTED HDL; CRYSTAL-STRUCTURE; ALKYLATING AGENT;
D O I：
10.2174/0929867322666150716114625
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The integration of lipoprotein-related or apolipoprotein-targeted nanoparticles as pharmaceutical carriers opens new therapeutic and diagnostic avenues in nanomedicine. The concept is to exploit the intrinsic characteristics of lipoprotein particles as being the natural transporter of apolar lipids and fat in human circulation. Discrete lipoprotein assemblies and lipoprotein-based biomimetics offer a versatile nanoparticle platform that can be manipulated and tuned for specific medical applications. This article reviews the possibilities for constructing drug loaded, reconstituted or artificial lipoprotein particles. The advantages and limitations of lipoproteinbased delivery systems are critically evaluated and potential future challenges, especially concerning targeting specificity, concepts for lipoprotein rerouting and design of innovative lipoprotein mimetic particles using apolipoprotein sequences as targeting moieties are discussed. Finally, the review highlights potential medical applications for lipoprotein-based nanoparticle systems in the fields of cardiovascular research, cancer therapy, gene delivery and brain targeting focusing on representative examples from literature.
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收藏
页码：3631 / 3651
页数：21
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