4-benchrotrenyl pyrylium salts as protein organometallic labelling reagents

被引：24

作者：

Caro, B

Le Guen-Robin, F

Salmain, M

Jaouen, G

机构：

[1] Ecole Natl Super Chim Paris, Lab Chim Organomet, CNRS, UMR 7576, F-75231 Paris 05, France

[2] IUT, Lab Chim Organomet & Biol, CNRS, UMR 6509, F-22302 Lannion, France

来源：

TETRAHEDRON | 2000年 / 56卷 / 02期

关键词：

D O I：

10.1016/S0040-4020(99)00947-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrylium ions are useful reagents to selectively modify the amino group of protein lysine residues. This property was exploited here to label proteins with chromium tricarbonyl complexes in the form of 4-benchrotrenyl pyridinium ions. Kinetic studies of the reaction of a series of benchrotrenyl pyrylium salts with water and n-butylamine were performed and revealed that the overall reactivity of these compounds was highly dependent on their substitution pattern. These compounds could find application in protein X-ray crystallography. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：257 / 263

页数：7

共 22 条

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[3]

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