An Overview of Partial Synthesis and Transformations of Secosteroids

被引：18
作者：
Gasi, Katarina Penov [1 ]
Sakac, Marija [1 ]
Jovanovic-Santa, Suzana [1 ]
Djurendic, Evgenija [1 ]
机构：
[1] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Novi Sad 21000, Serbia
来源：
CURRENT ORGANIC CHEMISTRY | 2014年 / 18卷 / 02期
关键词：
Secosteroids; partial synthesis; reactivity; modification; BECKMANN FRAGMENTATION REACTION; CONTAINING D-HOMOESTRONE; RAY CRYSTAL-STRUCTURE; BIOLOGICAL EVALUATION; AZA-STEROIDS; PHOTOINDUCED TRANSFORMATIONS; INTRAMOLECULAR CYCLIZATION; STEREOSELECTIVE SYNTHESIS; OXIDATION-PRODUCTS; RADICAL OXIDATION;
D O I：
10.2174/13852728113176660147
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Secosteroids are an important group of modified steroids, which exhibits a variety of different biological activities. Studies on secosteroids have shown that modifications of the rigid tetracyclic steroidal carbon skeleton by cleavage of the internal C-C bonds provides more flexible compounds with new biological properties. The search for steroid compounds analogs with improved biological properties includes ring transformation into seco system. The recent development in the partial syntheses of secosteroids is described herein, as well as studies of methods for modifications of such molecules.
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页码：216 / 259
页数：44
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