Association between interleukin-4-590C > T polymorphism and non-Hodgkin's lymphoma risk

被引：1

作者：

Zhou, Cuiling ^{[1
]}

Cui, Shouyong ^{[2
]}

Zhou, Rongjiao ^{[3
]}

Dou, Lianfeng ^{[2
]}

机构：

[1] Binzhou Med Univ Hosp, Dept Hematol, Binzhou 256603, Shandong, Peoples R China

[2] Binzhou Med Univ Hosp, Dept Emergency, Binzhou 256603, Shandong, Peoples R China

[3] Binzhou Med Univ Hosp, Dept Lab Med, Binzhou 256603, Shandong, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 04期

关键词：

IL-4; Polymorphism; Meta-analysis; NHL; Risk; PROSTATE-CANCER; IMMUNOREGULATORY GENES; CYTOKINE; METAANALYSIS; PUBLICATION; EXPRESSION; VARIANTS; PATHWAY; TRIALS; NUCB2;

D O I：

10.1007/s13277-013-1394-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many studies were performed to assess the association between IL-4 -590C > T polymorphism and non-Hodgkin's lymphoma (NHL) risk, but no consensus was available up to now. We conducted a meta-analysis to examine the association between IL-4 -590C > T polymorphism and NHL risk. We used odds ratios (ORs) to assess the strength of the association and 95 % confidence intervals (CIs) to give a sense of the precision of the estimate. A total of six studies were found to be eligible for meta-analyses of IL-4 -590C > T variant. Results from this study showed that IL-4 -590C > T polymorphism was not significantly associated with NHL risk under all genetic models in overall population. Further sensitivity analysis confirmed the results. In subgroup analyses stratified by race, no significant association was found in either Caucasian or mixed populations. The meta-analysis indicated that elected -590C > T polymorphism of IL-4 may not be a risk factor for NHL development.

引用

页码：3041 / 3045

页数：5

共 26 条

[1] Genetic variants in immunoregulatory genes and risk for childhood lymphomas [J].

Andrie, Elisabeth ;

Michos, Athanasios ;

Kalampoki, Vassiliki ;

Pourtsidis, Apostolos ;

Moschovi, Maria ;

Polychronopoulou, Sophia ;

Athanasiadou-Piperopoulou, Fani ;

Kalmanti, Maria ;

Hatzakis, Angelos ;

Paraskevis, Dimitrios ;

Nieters, Alexandra ;

Petridou, Eleni Th .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2009, 83 (04) :334-342

[2] Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials [J].

Cuppone, Federica ;

Bria, Emilio ;

Vaccaro, Vanja ;

Puglisi, Fabio ;

Fabi, Alessandra ;

Sperduti, Isabella ;

Carlini, Paolo ;

Milella, Michele ;

Nistico, Cecilia ;

Russillo, Michelangelo ;

Papaldo, Paola ;

Ferretti, Gianluigi ;

Aapro, Matti ;

Giannarelli, Diana ;

Cognetti, Francesco .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2011, 30

[3] Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells [J].

Dave, SS ;

Wright, G ;

Tan, B ;

Rosenwald, A ;

Gascoyne, RD ;

Chan, WC ;

Fisher, RI ;

Braziel, RM ;

Rimsza, LM ;

Grogan, TM ;

Miller, TP ;

LeBlanc, M ;

Greiner, TC ;

Weisenburger, DD ;

Lynch, JC ;

Vose, J ;

Armitage, JO ;

Smeland, EB ;

Kvaloy, S ;

Holte, H ;

Delabie, J ;

Connors, JM ;

Lansdorp, PM ;

Ouyang, Q ;

Lister, TA ;

Davies, AJ ;

Norton, AJ ;

Muller-Hermelink, HK ;

Ott, G ;

Campo, E ;

Montserrat, E ;

Wilson, WH ;

Jaffe, ES ;

Simon, R ;

Yang, LM ;

Powell, J ;

Zhao, H ;

Goldschmidt, N ;

Chiorazzi, M ;

Staudt, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (21) :2159-2169

[4] FACTORS INFLUENCING PUBLICATION OF RESEARCH RESULTS - FOLLOW-UP OF APPLICATIONS SUBMITTED TO 2 INSTITUTIONAL REVIEW BOARDS [J].

DICKERSIN, K ;

MIN, YI ;

MEINERT, CL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (03) :374-378

[5] PUBLICATION BIAS IN CLINICAL RESEARCH [J].

EASTERBROOK, PJ ;

BERLIN, JA ;

GOPALAN, R ;

MATTHEWS, DR .

LANCET, 1991, 337 (8746) :867-872

[6] Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials [J].

Ioannidis, JPA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (04) :281-286

[7] Cytokines: Principles and prospects [J].

Kelso, A .

IMMUNOLOGY AND CELL BIOLOGY, 1998, 76 (04) :300-317

[8] Cytokine polymorphisms in the Tb1/Th2 pathway and susceptibility to non-Hodgkin lymphoma [J].

Lan, Qing ;

Zheng, Tongzhang ;

Rothman, Nathaniel ;

Zhang, Yawei ;

Wang, Sophia S. ;

Shen, Min ;

Berndt, Sonja I. ;

Zahm, Shelia H. ;

Holford, Theodore R. ;

Leaderer, Brian ;

Yeager, Meredith ;

Welch, Robert ;

Boyle, Peter ;

Zhang, Bing ;

Zou, Kaiyong ;

Zhu, Yong ;

Chanock, Stephen .

BLOOD, 2006, 107 (10) :4101-4108

[9] Interleukin-10: new perspectives on an old cytokine [J].

Mosser, David M. ;

Zhang, Xia .

IMMUNOLOGICAL REVIEWS, 2008, 226 :205-218

[10] Haplotypes of the 5′ region of the IL-4 gene and SNPs in the intergene sequence between the IL-4 and IL-13 genes are associated with atopic asthma [J].

Noguchi, E ;

Nukaga-Nishio, Y ;

Jian, Z ;

Yokouchi, Y ;

Kamioka, M ;

Yamakawa-Kobayashi, K ;

Hamaguchi, H ;

Matsui, A ;

Shibasaki, M ;

Arinami, T .

HUMAN IMMUNOLOGY, 2001, 62 (11) :1251-1257

← 1 2 3 →

Association between interleukin-4-590C &gt; T polymorphism and non-Hodgkin's lymphoma risk

Association between interleukin-4-590C > T polymorphism and non-Hodgkin's lymphoma risk