Activation of Mitochondrial Uncoupling Protein 4 and ATP-Sensitive Potassium Channel Cumulatively Decreases Superoxide Production in Insect Mitochondria

被引：9

作者：

Slocinska, Malgorzata ^{[1
]}

Rosinski, Grzegorz ^{[1
]}

Jarmuszkiewicz, Wieslawa ^{[2
]}

机构：

[1] Adam Mickiewicz Univ, Dept Anim Physiol & Dev, PL-61614 Poznan, Poland

[2] Adam Mickiewicz Univ, Dept Bioenerget, PL-61614 Poznan, Poland

来源：

PROTEIN AND PEPTIDE LETTERS | 2016年 / 23卷 / 01期

关键词：

Insects; mitochondria; mitochondrial ATP-regulated channel (mK(ATP) channel); superoxide production; uncoupling protein 4 (UCP4); FUNCTIONAL-CHARACTERIZATION; K+ CHANNELS; FAT-BODY; IDENTIFICATION; TRANSPORT;

D O I：

10.2174/0929866523666151106121943

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been evidenced that mitochondrial uncoupling protein 4 (UCP4) and ATP-regulated potassium channel (mKATP channel) of insect Gromphadorhina coqereliana mitochondria decrease superoxide anion production. We elucidated whether the two energy-dissipating systems work together on a modulation of superoxide level in cockroach mitochondria. Our data show that the simultaneous activation of UCP4 by palmitic acid and mKATP channel by pinacidil revealed a cumulative effect on weakening mitochondrial superoxide formation. The inhibition of UCP4 by GTP (and/or ATP) and mKATP channel by ATP elevated superoxide production. These results suggest a functional cooperation of both energy-dissipating systems in protection against oxidative stress in insects.

引用

页码：63 / 68

页数：6

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