Visual rehabilitation training alters attentional networks in hemianopia: An fMRI study

被引:9
作者
Lu, Qilin [1 ,2 ,3 ]
Wang, Xiaoxiao [1 ,2 ,3 ,4 ]
Li, Lin [1 ,2 ,3 ]
Qiu, Bensheng [4 ]
Wei, Shihui [5 ]
Sabel, Bernhard A. [6 ]
Zhou, Yifeng [1 ,2 ,3 ]
机构
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China
[2] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
[3] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
[4] Univ Sci & Technol China, Ctr Biomed Engn, Hefei, Anhui, Peoples R China
[5] Chinese Peoples Liberat Army Gen Hosp, Dept Ophthalmol, Beijing, Peoples R China
[6] Otto von Guericke Univ, Med Fac, Inst Med Psychol, Magdeburg, Germany
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Brain plasticity; Brain lesion; Perceptual learning; Temporoparietal junction; Stimulus-driven attention network; INTRINSIC FUNCTIONAL CONNECTIVITY; VISION RESTORATION THERAPY; TEMPOROPARIETAL JUNCTION; RESIDUAL VISION; BRAIN; FIELD; ACTIVATION; CORTEX; REPRESENTATION; STIMULATION;
D O I
10.1016/j.clinph.2018.05.027
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Hemianopia is a visual field defect following post-chiasmatic damage. We now applied functional magnetic resonance imaging (fMRI) in hemianopic patients before and after visual rehabilitation training (VRT) to examine the impact of VRT on attentional function networks. Methods: Seven chronic hemianopic patients with post-chiasmatic lesions carried out a VRT for five weeks under fixation control. Before vs. after intervention, we assessed the area of residual vision (ARV), contrast sensitivity function (CSF) and functional MRI data and correlated them with each other. Results: VRT significantly improved the visual function of grating detection at the training location. Using fMRI, we found that the training led to a strengthening of connectivity between the right temporoparietal junction (rTPJ) to the insula and the anterior cingulate cortex (ACC), all of which belong to the cortical attentional network. However, no significant correlation between alterations of brain activity and improvements of either CSF or ARV was found. Conclusion: Visual rehabilitation training partially restored the deficient visual field sectors and could improve attentional network function in hemianopia. Significance: Our MRI results highlight the role of attention and the rTPJ activation as one, but not the only, component of VRT in hemianopia. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1832 / 1841
页数:10
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