Synthesis of novel (E)-N′-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives and their antimicrobial activity

被引：5
|
作者：
Mallikarjunaswamy, C. [1 ]
Bhadregowda, D. G. [1 ]
Mallesha, L. [2 ]
机构：
[1] Univ Mysore, Yuvarajas Coll, Dept Chem, Mysore 570005, Karnataka, India
[2] JSS Coll Arts Commerce & Sci, PG Dept Chem, Ooty Rd, Mysore 570025, Karnataka, India
来源：
JOURNAL OF SAUDI CHEMICAL SOCIETY | 2016年 / 20卷
关键词：
Pyrimidines; Schiff bases; Antimicrobial activity; Antifungal activity; BIOLOGICAL EVALUATION; AGENTS;
D O I：
10.1016/j.jscs.2013.04.005
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel (E)-N'-(2-chloropyrimidin-4-yl)-N-(5-cyano-2-hydroxy-6-phenylpyrimidin-4-yl) formamidine derivatives were synthesized by the reaction of different aldehydes with 2-chloropyrimidin-4-amine and in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, H-1 NMR and LC-MS spectral studies. Antimicrobial data revealed that among all the compounds screened, compounds 7l and 7m were found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：S606 / S614
页数：9
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