Reconciling the numbers: ESTs versus protein-coding genes

被引：13
|
作者：
Nekrutenko, A [1 ]
机构：
[1] Penn State Univ, Huck Inst Life Sci, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
[2] Penn State Univ, Ctr Comparat Genomics & Bioinformat, University Pk, PA 16802 USA
来源：
MOLECULAR BIOLOGY AND EVOLUTION | 2004年 / 21卷 / 07期
关键词：
protein-coding genes; human; mouse; comparative genome analysis; ESTs;
D O I：
10.1093/molbev/msh125
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9% to 14% of human-expressed and mouse-expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only approximately 20,000 distinct protein-coding transcripts.
引用
收藏
页码：1278 / 1282
页数：5
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