Reconciling the numbers: ESTs versus protein-coding genes

被引：13

作者：

Nekrutenko, A ^{[1
]}

机构：

[1] Penn State Univ, Huck Inst Life Sci, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

[2] Penn State Univ, Ctr Comparat Genomics & Bioinformat, University Pk, PA 16802 USA

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2004年 / 21卷 / 07期

关键词：

protein-coding genes; human; mouse; comparative genome analysis; ESTs;

D O I：

10.1093/molbev/msh125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9% to 14% of human-expressed and mouse-expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only approximately 20,000 distinct protein-coding transcripts.

引用

页码：1278 / 1282

页数：5

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