Copper- Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C-H Zincation**

被引：79

作者：

McDonald, Stacey L. ^{[1
]}

Hendrick, Charles E. ^{[1
]}

Wang, Qiu ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 18期

关键词：

amination; CH functionalization; copper; heterocycles; synthetic methods; DIRECTED ORTHO-METALATION; CENTER-DOT-LICL; CHEMOSELECTIVE BASE; OXIDATIVE AMINATION; ROOM-TEMPERATURE; MILD CONDITIONS; N-CHLOROAMINES; ARYL HALIDES; AMIDATION; AMINES;

D O I：

10.1002/anie.201311029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct amination of heteroarenes and arenes has been achieved in a one-pot CH zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.

引用

页码：4667 / 4670

页数：4

共 92 条

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[2]

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