Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells

被引：91

作者：

Jose Garcia-Nebot, Maria ^{[1
]}

Recio, Isidra ^{[1
]}

Hernandez-Ledesma, Blanca ^{[1
]}

机构：

[1] CEI UAM CSIC, Inst Invest Ciencias Alimentac CIAL, CSIC UAM, Madrid 28049, Spain

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 65卷

关键词：

Peptide lunasin; Antioxidant; Oxidative stress; Intestinal health; TERT-BUTYL HYDROPEROXIDE; IN-VITRO; BETA-LACTOGLOBULIN; HYDROGEN-PEROXIDE; OXYGEN; MILK; HYDROLYSIS; EXPRESSION; FLAVONOIDS; CULTURE;

D O I：

10.1016/j.fct.2013.12.021

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Oxidative stress is one of the most critical factors implicated in many disorders of the gastrointestinal tract, such as inflammatory bowel diseases and colon cancer. Lunasin is a seed peptide known by its properties against cancer and cardiovascular diseases. The present study investigated the in vitro antioxidant activity of this peptide that demonstrated to be a potent scavenger of peroxyl and superoxide radicals. in addition, the protective role of lunasin on cell viability and antioxidant defenses of human Caco-2 cells challenged by hydrogen peroxide and tert-butylhydroperoxide was evaluated. This peptide remained partially intact during incubation time with cells, preventing of the oxidative damage induced by both chemical agents. The direct antioxidant action of lunasin (within the physiological range of concentrations) on enterocytes exposed to oxidizing species makes this peptide a promising agent to preserve the integrity of intestinal mucosa against oxidative damage related diseases. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：155 / 161

页数：7

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