Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?

被引：10
|
作者：
Prytula, Agnieszka [1 ]
Cransberg, Karlien [2 ]
Raes, Ann [1 ,3 ]
机构：
[1] Ghent Univ Hosp, Paediat Nephrol & Rheumatol Dept, C Heymanslaan 10, B-9000 Ghent, Belgium
[2] Sophia Childrens Univ Hosp, Erasmus MC, Paediat Nephrol Dept, Rotterdam, Netherlands
[3] Safepedrug Unit, Ghent, Belgium
来源：
PEDIATRIC NEPHROLOGY | 2019年 / 34卷 / 07期
关键词：
Calcineurin inhibitors; CYP3A; CYP3A4; CYP3A5; Vitamin D; Mineral and bone disorder; Renal transplantation; SINGLE NUCLEOTIDE POLYMORPHISMS; CYCLOSPORINE-A; IN-VITRO; BONE LOSS; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; CALCINEURIN INHIBITORS; GENETIC POLYMORPHISMS; MINERAL METABOLISM; DOSE REQUIREMENTS; LIVER;
D O I：
10.1007/s00467-018-4030-3
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
CYP3A enzymes are involved in the metabolism of calcineurin inhibitor tacrolimus as well as vitamin D. In this review, we summarize the clinical aspects of CYP3A-mediated metabolism of tacrolimus and vitamin D with emphasis on the influence of single-nucleotide polymorphisms on tacrolimus disposition. We describe the utility of 4 hydroxycholesterol as a marker of CYP3A activity. Then, we discuss the possible interaction between calcineurin inhibitors and vitamin D in solid organ transplant recipients. Also, we review other mechanisms which may contribute to side effects of calcineurin inhibitors on bone. Lastly, suggestions for future research and clinical perspectives are discussed.
引用
收藏
页码：1201 / 1210
页数：10
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