Acquisition of structural information on glycosaminoglycans by using mass spectrometry

被引：5
作者：
Minamisawa, Toshikazu
Hirabayashi, Jun
机构：
[1] Natl Inst Adv Ind Sci & Technol, Res Ctr Glycosci, Tsukuba, Ibaraki 3058568, Japan
[2] Seikagaku Corp, Cent Res Labs, Dept Med Resources, Tokyo 2070021, Japan
来源：
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 2006年 / 18卷 / 103期
关键词：
fragmentation; glycosaminoglycan; isomer; mass spectrometry; oligosaccharide; sequence;
D O I：
10.4052/tigg.18.293
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural complexity and heterogeneity of glycosaminoglycans (GAGs) have troubled biochemists in the research field for many years, thereby the progress of its functional research has long been delayed. Recently, rapid progress in mass spectrometry (MS), especially a tandem MS that can perform MS/MS (MSn) experiments, has lead to its increasing use for structural studies of GAGs. By using MS, though still under research, it is becoming possible to obtain information on not only molecular weights of GAG oligosaccharides but also position of sulfation, epimerization of a uronic acid, and more detail on the oligosaccharide sequence. Further refinement of MS methodology is expected to accelerate biochemical research of GAGs as well their medical applications.
引用
收藏
页码：293 / 312
页数：20
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