Genomic analysis of the adenylate cyclase-hemolysin C-terminal region of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica

被引：16
作者：
Chenal-Francisque, Viviane [1 ]
Caro, Valerie [1 ]
Boursaux-Eude, Caroline [1 ]
Guiso, Nicole [1 ]
机构：
[1] Inst Pasteur, CNRS, URA 3012, Unite Prevent & Therapie Mol Malad Humaines, F-75724 Paris 15, France
来源：
RESEARCH IN MICROBIOLOGY | 2009年 / 160卷 / 05期
关键词：
Bordetella; Adenylate cyclase-hemolysin; cyaA gene; TOXIN; POLYMORPHISM; VIRULENCE; EVOLUTION; SOFTWARE; GENETICS; DOMAIN; HOST;
D O I：
10.1016/j.resmic.2009.03.006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Adenylate cyclase-hemolysin plays an important role in the virulence of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica species. Its C-terminal region carries protective epitopes and receptor binding site for human cells. Genomic analyses of this region indicate no polymorphism in B. pertussis and B. parapertussis regions, but substantial variability in B. bronchiseptica that might be linked to the various niches of this species. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：330 / 336
页数：7
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