Directed ring-closing metathesis of trienes by silyl substitution

被引：10

作者：

Schultz-Fademrecht, C

Deshmukh, PH

Malagu, K

Procopiou, PA

Barrett, AGM ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] GlaxoSmithKline Res & Dev Ltd, Dept Med Chem, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON | 2004年 / 60卷 / 35期

基金：

英国工程与自然科学研究理事会;

关键词：

ring-closing metathesis; crossed metathesis; ruthenium catalysts; macrocyclization;

D O I：

10.1016/j.tet.2004.05.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic strategy for 'disarming' a terminal alkene by substitution with a bulky silyl blocking group has been developed. In a series of model studies, sequential selective ring-closing metathesis of trienes followed by selective mono-hydrogenation of the resulting diene is described. The bulky silylated alkene is activated for a subsequent cross-metathesis reaction with a range of diverse alkenes by protodesilylation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7515 / 7524

页数：10

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