Acetal containing polymers as pH-responsive nano-drug delivery systems

被引：92
|
作者：
Gannimani, Ramesh [1 ]
Walvekar, Pavan [1 ,3 ]
Naidu, Veluru Ramesh [2 ]
Aminabhavi, Tejraj M. [3 ]
Govender, Thirumala [1 ]
机构：
[1] Univ KwaZulu Natal, Sch Hlth Sci, Discipline Pharmaceut Sci, Private Bag X54001, ZA-4000 Durban, South Africa
[2] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden
[3] SETs Coll Pharm, Dept Pharmaceut, Dharwad 580002, Karnataka, India
来源：
JOURNAL OF CONTROLLED RELEASE | 2020年 / 328卷
基金：
英国医学研究理事会; 新加坡国家研究基金会;
关键词：
Acetal; pH-responsive; Polymers; Nano drug delivery; Cancer; Bacterial infection; DEGRADABLE CHIMERIC POLYMERSOMES; ACID-CATALYZED HYDROLYSIS; INTRACELLULAR RELEASE; EFFICIENT SYNTHESIS; BENZYLIDENE ACETAL; TRIGGERED RELEASE; ENDOSOMAL-ESCAPE; GRAFT COPOLYMER; NANOPARTICLES; MICELLES;
D O I：
10.1016/j.jconrel.2020.09.044
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Utilization of unique acidic environment in various disease sites has been quite advantageous in targeted drug delivery. Among the widely explored pH-sensitive moieties such as hydrazone, orthoester, imine, vinylether, etc., the acetal bearing compounds are one of the most explored entities in targeted and improved drug delivery to treat disease conditions at the preclinical stage. This review addresses the design and synthesis of various acetalbased polymers as pH-responsive nano-drug delivery systems in the form of micelles, polymersomes, nanoplexes and polymeric and solid lipid nanoparticles for biomedical applications. The review will identify potential advantages, key challenges and future prospects of acetal-based pH-responsive drug delivery systems. The novel developments, strategies and suggestions described may guide the formulation scientists to optimize acetalbased pH-responsive drug delivery systems as an approach to treat various diseases.
引用
收藏
页码：736 / 761
页数：26
相关论文
共 50 条
  • [1] pH-responsive polymers for drug delivery: Trends and opportunities
    Singh, Jagtar
    Nayak, Pallavi
    JOURNAL OF POLYMER SCIENCE, 2023, 61 (22) : 2828 - 2850
  • [2] Thermo- and pH-responsive polymers in drug delivery
    Schmaljohann, Dirk
    ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (15) : 1655 - 1670
  • [3] Efficient pH-Responsive Nano-Drug Delivery System Based on Dynamic Boronic Acid/Ester Transformation
    Chen, Weijun
    Xie, Wanxuan
    Zhao, Guangkuo
    Shuai, Qi
    MOLECULES, 2023, 28 (11):
  • [4] pH-Responsive Drug-Delivery Systems
    Zhu, Ying-Jie
    Chen, Feng
    CHEMISTRY-AN ASIAN JOURNAL, 2015, 10 (02) : 284 - 305
  • [5] pH-responsive polymeric vesicles as drug delivery systems
    Dubos, Ashley
    Fish, Daryle
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [6] Preparation and application of pH-responsive drug delivery systems
    Ding, Haitao
    Tan, Ping
    Fu, Shiqin
    Tian, Xiaohe
    Zhang, Hu
    Ma, Xuelei
    Gu, Zhongwei
    Luo, Kui
    JOURNAL OF CONTROLLED RELEASE, 2022, 348 : 206 - 238
  • [7] Catechol Polymers for pH-Responsive, Targeted Drug Delivery to Cancer Cells
    Su, Jing
    Chen, Feng
    Cryns, Vincent L.
    Messersmith, Phillip B.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (31) : 11850 - 11853
  • [8] pH-Responsive Nanoparticles for Drug Delivery
    Gao, Weiwei
    Chan, Juliana M.
    Farokhzad, Omid C.
    MOLECULAR PHARMACEUTICS, 2010, 7 (06) : 1913 - 1920
  • [9] pH-Responsive Hybrid Hydrogels as Antibacterial and Drug Delivery Systems
    Sattari, Shabnam
    Tehrani, Abbas Dadkhah
    Adeli, Mohsen
    POLYMERS, 2018, 10 (06):
  • [10] Coordination bonding based pH-responsive drug delivery systems
    Zheng, Haoquan
    Xing, Lei
    Cao, Yuanyuan
    Che, Shunai
    COORDINATION CHEMISTRY REVIEWS, 2013, 257 (11-12) : 1933 - 1944
12345