Reverse seroconversion of hepatitis B virus after allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease

被引：5

作者：

Oshima, Kumi

Sato, Miki

Okuda, Shinya

Terasako, Kiriko

Nakasone, Hideki

Kako, Shinichi

Yamazaki, Rie

Tanaka, Yukie

Tanihara, Aki

Higuchi, Takakazu

Nishida, Junji

Nakamura, Ikuo ^{[2
]}

Yoshida, Yukio ^{[2
]}

Kanda, Yoshinobu ^{[1
]}

机构：

[1] Jichi Med Univ, Saitama Med Ctr, Div Hematol, Omiya Ku, Saitama 3308503, Japan

[2] Jichi Med Univ, Saitama Med Ctr, Div Gastroenterol, Saitama 3308503, Japan

来源：

HEMATOLOGY | 2009年 / 14卷 / 02期

关键词：

Hematopoietic stem cell transplantation; hepatitis B virus; reverse seroconversion; graft-versus-host disease; OF-THE-LITERATURE; BONE-MARROW-TRANSPLANTATION; ACUTE VIRAL-HEPATITIS; INFECTION; REACTIVATION; RECIPIENTS; LAMIVUDINE; RECOVERY;

D O I：

10.1179/102453309X385223

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The appearance of hepatitis B surface antigen (HBsAg) in patients previously positive for antibody to this antigen (HBsAb) is called reverse seroconversion, a rare complication after hematopoietic stem cell transplantation (HSCT), which occurs almost exclusively after HSCT from an HBsAb-negative donor and the development of chronic graft-versus-host disease (CGVHD). However, we experienced a patient who developed reverse seroconversion 23 months after unrelated HSCT even in the absence of immunosuppressants use or CGVHD. Serum immunoglobulin level was persistently normal. Therefore, all HBsAb-positive recipients should be considered to be at risk for HBV reactivation, even in patients without any risk factors.

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页码：73 / 75

页数：3

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