CD20-mediated apoptosis: signalling through lipid rafts

被引：186

作者：

Deans, JP ^{[1
]}

Li, HD ^{[1
]}

Polyak, MJ ^{[1
]}

机构：

[1] Univ Calgary, Dept Biochem & Mol Biol, Immunol Res Grp, Calgary, AB T2N 4N1, Canada

来源：

IMMUNOLOGY | 2002年 / 107卷 / 02期

关键词：

D O I：

10.1046/j.1365-2567.2002.01495.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.

引用

页码：176 / 182

页数：7

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