Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae)

被引：71

作者：

Menichini, Federica ^{[1
]}

Tundis, Rosa ^{[1
]}

Loizzo, Monica R. ^{[1
]}

Bonesi, Marco ^{[1
]}

Marrelli, Mariangela ^{[1
]}

Statti, Giancarlo A. ^{[1
]}

Menichini, Francesco ^{[1
]}

Conforti, Filomena ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharmaceut Sci, Fac Pharm Nutr & Hlth Sci, I-87036 Arcavacata Di Rende, CS, Italy

来源：

FITOTERAPIA | 2009年 / 80卷 / 05期

关键词：

Aromatic plant; Cholinesterase inhibition activity; Pimpinella anisoides; Terpenes; Apiaceae; ANTIOXIDANT; L;

D O I：

10.1016/j.fitote.2009.03.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibited activity against AChE and BChE, with IC50 values of 227.5 and 362.1 mu g/ml, respectively. The most abundant constituents of the extract were trans-anethole, (+)-limonene and (+)-sabinene. trans-Anethole exhibited the highest activity against AChE and BChE with IC50 values of 134.7 and 209.6 mu g/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC50 of 176.5 mu g/ml) and BChE (IC50 of 218.6 mu g/ml). (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：297 / 300

页数：4

共 16 条

[1]

ADAMS R P., 2004, Identification of essential oil components by gas chromatography/ quadrupole mass spectroscopy

[2]

[Anonymous], SEEDS CATALOGUE CROP

[3]

Ballard Clive G., 2005, Current Alzheimer Research, V2, P307

[4]

BASER KHC, 2002, P 8 INT S NAT PROD C, P271