Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia: A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

被引：12

作者：

Ruggeri, Annalisa ^{[1
,2
,3
]}

Galimard, Jacques-Emmanuel ^{[4
]}

Labopin, Myriam ^{[4
]}

Rafii, Hanadi ^{[2
,3
]}

Blaise, Didier ^{[5
]}

Ciceri, Fabio ^{[1
]}

Diez-Martin, Jose-Luiz ^{[6
]}

Cornelissen, Jan ^{[7
]}

Chevallier, Patrice ^{[8
]}

Sanchez-Guijo, Fermin ^{[9
]}

Nicholson, Emma ^{[10
]}

Castagna, Luca ^{[11
]}

Forcade, Edouard ^{[12
]}

Kuball, Jurgen ^{[13
]}

Rovira, Montserrat ^{[14
]}

Koc, Yener ^{[15
]}

Pavlu, Jiri ^{[16
]}

Gulbas, Zafar ^{[17
]}

Vydra, Jan ^{[18
]}

Baron, Frederic ^{[19
]}

Sanz, Jaime ^{[20
,21
]}

Spyridonidis, Alexandros ^{[22
]}

Savani, Bipin ^{[23
]}

Gluckman, Eliane ^{[2
,3
,24
]}

Nagler, Arnon ^{[25
]}

Mohty, Mohamad ^{[4
,26
]}

机构：

[1] Ist Sci San Raffaele, Hematol & BMT Unit, Via Olgettina 60, I-20135 Milan, Italy

[2] Hop St Louis, Eurocord, Paris, France

[3] IUH Univ Paris VII, Paris, France

[4] Hop St Antoine, AP HP, Hematol & Cellular Therapy Serv, Paris, France

[5] Inst Paoli Calmettes, Marseille, France

[6] Univ Complutense Madrid, Inst Invest Sanitaria Gregorio Maranon, Hosp GU Gregorio Maranon, Hematol Dept,Dept Med, Madrid, Spain

[7] Univ Med Ctr, Erasmus MC Canc Inst, Rotterdam, Netherlands

[8] Hop Hotel Dieu, Hematol Serv, Nantes, France

[9] Univ Hosp Salamanca, Hematol Dept, USAL IBSAL, Salamanca, Spain

[10] Royal Marsden Hosp, Dept Haematol, London, England

[11] Humanitas Canc Ctr, Rozzano, Italy

[12] CHU Bordeaux, Hop Haut Leveque, Bordeaux, France

[13] Univ Med Ctr, Dept Hematol, Utrecht, Netherlands

[14] Hosp Clin Barcelona, Inst Hematol & Oncol, Inst Josep Carreras, BMT Unit,Dept Hematol, Barcelona, Spain

[15] Medicana Int, Istanbul, Turkey

[16] Imperial Coll, Hammersmith Hosp, Dept Haematol, London, England

[17] Anadolu Med Ctr Hosp, Bone Marrow Transplantat Dept, Istanbul, Turkey

[18] Inst Hematol & Blood Transfus, Prague, Czech Republic

[19] CHU Liege, Dept Hematol, Liege, Belgium

[20] Hosp Univ & Politecn La Fe, Valencia, Spain

[21] CIBERONC, Madrid, Spain

[22] Univ Hosp Patras, Patras, Greece

[23] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[24] Monacord, Ctr Sci Monaco, Vatican City, Monaco

[25] Tel Aviv Univ, Hematol Div, Chaim Sheba Med Ctr, Ramat Gan, Israel

[26] INSERM, UMR 938, Paris, France

来源：

TRANSPLANTATION AND CELLULAR THERAPY | 2022年 / 28卷 / 10期

关键词：

Acute myelogenous leukemia; Haploidentical transplant; Double cord blood; transplantation Post-transplantation; cyclophosphamide; BONE-MARROW; SINGLE; INFECTION; DONORS; IMPACT; TRIALS;

D O I：

10.1016/j.jtct.2022.07.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. In a population of adults with de novo AML in first or second CR, we compared outcomes after dUCBT (n = 165) and after haplo-PTCY PBSC (n = 544) performed between January 2013 and December 2018. Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. The median follow-up was 33 months for the haplo-PTCY arm and 52 months for the dUCBT arm. No statistically significant differences were observed between the 2 arms in the rates of grade II-IV acute graft-versus-host disease (GVHD) (hazard ratio [HR], 1.31; P =.18), grade III-IV acute GVHD (HR, 1.17; P =.56), chronic GVHD (HR,.86; P =.48), relapse (HR, 1.07; P =.77), nonrelapse mortality (NRM) (HR,.94; P =.77), leukemia-free survival (LFS) (HR,.99; P =.95), or overall survival (OS) (HR,.99; P =.97). Favorable cytogenetic risk was the sole factor predictive of lower relapse incidence (RI). Younger age at transplantation was associated with lower NRM and higher LFS and OS. Both dUCBT and haplo-PTCY with PBSCs can be considered valid approaches for adult AML patients in CR. New strategies should be investigated in both settings to define the most appropriate conditioning regimen and potentially decrease RI and NRM through better immune reconstitution and optimal supportive care. (c) 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

引用

页码：710.e1 / 710.e10

页数：10

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