Peptide-catalyzed kinetic resolution of planar-chiral metallocenes

被引：29

作者：

Akiyama, Midori ^{[1
]}

Akagawa, Kengo ^{[1
]}

Seino, Hidetake ^{[2
]}

Kudo, Kazuaki ^{[1
]}

机构：

[1] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan

[2] Akita Univ, Fac Educ & Human Studies, Akita 0108502, Japan

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 58期

关键词：

ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; ORTHO-LITHIATION; AMINO-ACID; FERROCENES; DERIVATIVES; COMPLEXES; ALKYLATION; CHEMISTRY; ACYLATION;

D O I：

10.1039/c4cc03266g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Kinetic resolution of racemic planar-chiral metallocenes was performed through the conjugate addition of a nucleophile to the enal part of substrates. While no enantiomeric discrimination was found with low-molecular-weight organocatalysts, a properly designed resin-supported peptide catalyzed the reaction in a highly selective manner.

引用

页码：7893 / 7896

页数：4

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