Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs

被引：320

作者：

Junyaprasert, Varaporn Buraphacheep ^{[1
,2
]}

Morakul, Boontida ^{[1
]}

机构：

[1] Mahidol Univ, Fac Pharm, Dept Pharm, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Pharm, Ctr Excellence Innovat Drug Delivery & Nanomed, Bangkok 10400, Thailand

来源：

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2015年 / 10卷 / 01期

关键词：

Nanocrystals; Bioavailability; Poorly water-soluble drugs; PARTICLE-SIZE REDUCTION; DERMAL DELIVERY; NANOSUSPENSION TECHNOLOGY; BEAGLE DOGS; FORMULATION; NANOPARTICLES; DISSOLUTION; ABSORPTION; SYSTEM; HOMOGENIZATION;

D O I：

10.1016/j.ajps.2014.08.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness to surface/cell membranes. Several strategies are applied for nanocrystals production including precipitation, milling, high pressure homogenization and combination methods such as Nano-Edge (TM), SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology. For oral administration, many publications reported useful advantages of nanocrystals to improve in vivo performances i.e. pharmacokinetics, pharmacodynamics, safety and targeted delivery which were discussed in this review. Additionally, transformation of nanocrystals to final formulations and future trends of nanocrystals were also described. (C) 2015 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V.

引用

页码：13 / 23

页数：11

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