The use of the non-fasting lipid profile for lipid-lowering therapy in clinical practice - Point of view

被引：21

作者：

de Vries, Marijke ^{[1
]}

Klop, Boudewijn ^{[1
]}

Cabezas, Manuel Castro ^{[1
]}

机构：

[1] St Franciscus Gasthuis, Diabet & Vasc Ctr, Dpt Internal Med, Rotterdam, Netherlands

来源：

ATHEROSCLEROSIS | 2014年 / 234卷 / 02期

关键词：

Non-fasting triglycerides; Apolipoprotein B; Non-HDL-C; FAMILIAL COMBINED HYPERLIPIDEMIA; DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-B; CARDIOVASCULAR EVENTS; PRACTICE GUIDELINE; LDL CHOLESTEROL; APO-B; RISK; TRIGLYCERIDES;

D O I：

10.1016/j.atherosclerosis.2014.03.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current guidelines for the management of dyslipidaemias recommend measuring lipid profiles in the fasting state. The primary lipid targets are traditionally plasma total cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels. However, triglycerides, apolipoprotein (apo) B and non-high-density lipoprotein-cholesterol (non-HDL-C) are also suitable parameters to assess cardiovascular risk and to guide lipid-lowering therapy. The advantage of the use of these variables is that they can be used in both the fasting and non-fasting state. In most cases, postprandial lipid profiles in combination with apo B are as useful as fasting lipid profiles for the differentiation between familial lipid disorders, such as heterozygous familial hypercholesterolemia, familial combined hyperlipidemia and familial hypertriglyceridemia. This article will address the interpretation, applications and limitations of a non-fasting lipid profile for daily clinical practice. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：473 / 475

页数：3

共 31 条

[1] Beyond Low-Density Lipoprotein Cholesterol [J].

Arsenault, Benoit J. ;

Rana, Jamal S. ;

Stroes, Erik S. G. ;

Despres, Jean-Pierre ;

Shah, Prediman K. ;

Kastelein, John J. P. ;

Wareham, Nicholas J. ;

Boekholdt, S. Matthijs ;

Khaw, Kay-Tee .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 55 (01) :35-41

[2] Small, dense LDL and elevated apolipoprotein B are the common characteristics for the three major lipid phenotypes of familial combined Hyperlipidemia [J].

Ayyobi, AF ;

McGladdery, SH ;

McNeely, MJ ;

Austin, MA ;

Motulsky, AG ;

Brunzell, JD .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (07) :1289-1294

[3] Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women [J].

Bansal, Sandeep ;

Buring, Julie E. ;

Rifai, Nader ;

Mora, Samia ;

Sacks, Frank M. ;

Ridker, Paul M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (03) :309-316

[4] Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel [J].

Barter, PJ ;

Ballantyne, CM ;

Carmena, R ;

Cabezas, MC ;

Chapman, MJ ;

Couture, P ;

De Graaf, J ;

Durrington, PN ;

Faergeman, O ;

Frohlich, J ;

Furberg, CD ;

Gagne, C ;

Haffner, SM ;

Humphries, SE ;

Jungner, I ;

Krauss, RM ;

Kwiterovich, P ;

Marcovina, S ;

Packard, CJ ;

Pearson, TA ;

Reddy, KS ;

Rosenson, R ;

Sarrafzadegan, N ;

Sniderman, AD ;

Stalenhoef, AF ;

Stein, E ;

Talmud, PJ ;

Tonkin, AM ;

Walldius, G ;

Williams, KMS .

JOURNAL OF INTERNAL MEDICINE, 2006, 259 (03) :247-258

[5] Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline [J].

Berglund, Lars ;

Brunzell, John D. ;

Goldberg, Anne C. ;

Goldberg, Ira J. ;

Sacks, Frank ;

Murad, Mohammad Hassan ;

Stalenhoef, Anton F. H. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (09) :2969-2989

[6] Association of LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins A Meta-analysis [J].

Boekholdt, S. Matthijs ;

Arsenault, Benoit J. ;

Mora, Samia ;

Pedersen, Terje R. ;

LaRosa, John C. ;

Nestel, Paul J. ;

Simes, R. John ;

Durrington, Paul ;

Hitman, Graham A. ;

Welch, K. M. A. ;

DeMicco, David A. ;

Zwinderman, Aeilko H. ;

Clearfield, Michael B. ;

Downs, John R. ;

Tonkin, Andrew M. ;

Colhoun, Helen M. ;

Gotto, Antonio M., Jr. ;

Ridker, Paul M. ;

Kastelein, John J. P. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (12) :1302-1309

[7]

BRUNZELL JD, 1983, J LIPID RES, V24, P147

[8] Hypertriglyceridemia [J].

Brunzell, John D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (10) :1009-1017

[9] ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) [J].

Catapano, Alberico L. ;

Reiner, Zeljko ;

De Backer, Guy ;

Graham, Ian ;

Taskinen, Marja-Riitta ;

Wiklund, Olov ;

Agewall, Stefan ;

Alegria, Eduardo ;

Chapman, M. John ;

Durrington, Paul ;

Erdine, Serap ;

Halcox, Julian ;

Hobbs, Richard ;

Kjekshus, John ;

Filardi, Pasquale Perrone ;

Riccardi, Gabriele ;

Storey, Robert F. ;

Wood, David .

ATHEROSCLEROSIS, 2011, 217 (01) :3-46

[10] High plasma level of remnant-like particles cholesterol in familial combined hyperlipidemia [J].

de Graaf, Jacqueline ;

van der Vleuten, Gerly M. ;

ter Avest, Ewoud ;

Dallinga-Thie, Geesje M. ;

Stalenhoef, Anton F. H. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (04) :1269-1275

← 1 2 3 4 →