Role of Obesity in Barrett's Esophagus and Cancer

被引：19
作者：
Murray, Liam [1 ]
Romero, Yvonne [2 ,3 ]
机构：
[1] Queens Univ Belfast, Ctr Publ Hlth, Belfast B12 6BJ, Antrim, North Ireland
[2] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Dept Med, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Dept Otorhinolaryngol, Rochester, MN 55905 USA
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 03期
关键词：
Reflux esophagitis; Barrett's esophagus; Esophageal adenocarcinoma; Obesity; Adiposity; BODY-MASS INDEX; GROWTH-FACTOR (IGF)-I; GASTROESOPHAGEAL-REFLUX DISEASE; PLASMA ADIPONECTIN LEVELS; RISK-FACTORS; COLORECTAL-CANCER; ABDOMINAL OBESITY; WEIGHT-LOSS; FAMILIAL AGGREGATION; ADENOCARCINOMA CELLS;
D O I：
10.1016/j.soc.2009.03.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The incidence of esophageal adenocarcinoma (EAC) has increased dramatically in the western world, and there also appears to have been an increase in the incidence of Barrett's esophagus and gastroesophageal reflux disease in recent years. The contemporaneous increase in obesity has focused interest on whether obesity is a risk factor for EAC and its precursors. This article reviews current evidence for the role that overweight/obesity and body fat distribution have in development of the esophagitis metaplasia-dysplasia-adenocarcinoma sequence. Particular attention is paid to the stage at which adiposity may act to influence the risk of EAC, because this determines the importance of weight control and weight loss at each stage in the disease spectrum for the prevention of EAC.
引用
收藏
页码：439 / +
页数：15
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