Role of Obesity in Barrett's Esophagus and Cancer

被引：19
作者：
Murray, Liam [1 ]
Romero, Yvonne [2 ,3 ]
机构：
[1] Queens Univ Belfast, Ctr Publ Hlth, Belfast B12 6BJ, Antrim, North Ireland
[2] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Dept Med, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Dept Otorhinolaryngol, Rochester, MN 55905 USA
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 03期
关键词：
Reflux esophagitis; Barrett's esophagus; Esophageal adenocarcinoma; Obesity; Adiposity; BODY-MASS INDEX; GROWTH-FACTOR (IGF)-I; GASTROESOPHAGEAL-REFLUX DISEASE; PLASMA ADIPONECTIN LEVELS; RISK-FACTORS; COLORECTAL-CANCER; ABDOMINAL OBESITY; WEIGHT-LOSS; FAMILIAL AGGREGATION; ADENOCARCINOMA CELLS;
D O I：
10.1016/j.soc.2009.03.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The incidence of esophageal adenocarcinoma (EAC) has increased dramatically in the western world, and there also appears to have been an increase in the incidence of Barrett's esophagus and gastroesophageal reflux disease in recent years. The contemporaneous increase in obesity has focused interest on whether obesity is a risk factor for EAC and its precursors. This article reviews current evidence for the role that overweight/obesity and body fat distribution have in development of the esophagitis metaplasia-dysplasia-adenocarcinoma sequence. Particular attention is paid to the stage at which adiposity may act to influence the risk of EAC, because this determines the importance of weight control and weight loss at each stage in the disease spectrum for the prevention of EAC.
引用
收藏
页码：439 / +
页数：15
相关论文
共 50 条
  • [21] Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis
    Kendall, Bradley J.
    Rubenstein, Joel H.
    Cook, Michael B.
    Vaughan, Thomas L.
    Anderson, Lesley A.
    Murray, Liam J.
    Shaheen, Nicholas J.
    Corley, Douglas A.
    Chandar, Apoorva K.
    Li, Li
    Greer, Katarina B.
    Chak, Amitabh
    El-Serag, Hashem B.
    Whiteman, David C.
    Thrift, Aaron P.
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2016, 14 (10) : 1412 - +
  • [22] Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use
    Kaz, Andrew M.
    Wong, Chao-Jen
    Varadan, Vinay
    Willis, Joseph E.
    Chak, Amitabh
    Grady, William M.
    CLINICAL EPIGENETICS, 2016, 8
  • [23] Risk factors and chemoprevention in Barrett's esophagus - an update
    Winberg, Hanna
    Lindblad, Mats
    Lagergren, Jesper
    Dahlstrand, Hanna
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2012, 47 (04) : 397 - 406
  • [24] Current status of Barrett's esophagus research in Asia
    Chang, Chi-Yang
    Cook, Michael B.
    Lee, Yi-Chia
    Lin, Jaw-Town
    Ando, Takafumi
    Bhatia, Shobna
    Chow, Wong-Ho
    El-Omar, Emad M.
    Goto, Hidemi
    Li, Yang-Qing
    McColl, Kenneth
    Reddy, Nageshwar
    Rhee, Poong-Lyul
    Sharma, Prateek
    Sung, Joseph J-Y
    Ghoshal, Uday
    Wong, Jennie Y-Y
    Wu, Justin C-Y
    Zhang, Jun
    Ho, Khek-Yu
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 26 (02) : 240 - 246
  • [25] The Role of Tobacco, Alcohol, and Obesity in Neoplastic Progression to Esophageal Adenocarcinoma: A Prospective Study of Barrett's Esophagus
    Hardikar, Sheetal
    Onstad, Lynn
    Blount, Patricia L.
    Odze, Robert D.
    Reid, Brian J.
    Vaughan, Thomas L.
    PLOS ONE, 2013, 8 (01):
  • [26] Barrett's Esophagus: A Review of the Literature
    Gilbert, Erin W.
    Luna, Renato A.
    Harrison, Vincent L.
    Hunter, John G.
    JOURNAL OF GASTROINTESTINAL SURGERY, 2011, 15 (05) : 708 - 718
  • [27] Barrett's esophagus
    Baretton, G. B.
    Aust, D. E.
    PATHOLOGE, 2012, 33 (01): : 5 - +
  • [28] Barrett's esophagus
    Phillips, Wayne A.
    Lord, Reginald V.
    Nancarrow, Derek J.
    Watson, David I.
    Whiteman, David C.
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 26 (04) : 639 - 648
  • [29] The risk of Barrett's esophagus associated with abdominal obesity in males and females
    Kendall, Bradley J.
    Macdonald, Graeme A.
    Hayward, Nicholas K.
    Prins, Johannes B.
    O'Brien, Suzanne
    Whiteman, David C.
    INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (09) : 2192 - 2199
  • [30] Association between obesity and Barrett's esophagus in a Japanese population: a hospital-based, cross-sectional study
    Watari, Jiro
    Hori, Kazutoshi
    Toyoshima, Fumihiko
    Kamiya, Noriko
    Yamasaki, Takahisa
    Okugawa, Takuya
    Asano, Haruki
    Li, Zhao Liang
    Kondo, Takashi
    Ikehara, Hisatomo
    Sakurai, Jun
    Tomita, Toshihiko
    Oshima, Tadayuki
    Fukui, Hirokazu
    Miwa, Hiroto
    BMC GASTROENTEROLOGY, 2013, 13
12345