NOVEL POXVIRUS INFECTION IN NORTHERN AND SOUTHERN SEA OTTERS (ENHYDRA LUTRIS KENYONI AND ENHYDRA LUTRIS NEIRIS), ALASKA AND CALIFORNIA, USA

被引：13

作者：

Tuomi, Pamela A. ^{[1
]}

Murray, Michael J. ^{[2
]}

Garner, Michael M. ^{[3
]}

Goertz, Caroline E. C. ^{[1
]}

Nordhausen, Robert W. ^{[4
]}

Burek-Huntington, Kathleen A. ^{[5
]}

Getzy, David M. ^{[6
]}

Nielsen, Ole ^{[7
]}

Archer, Linda L. ^{[8
]}

Maness, Heather T. D. ^{[8
]}

Wellehan, James F. X., Jr. ^{[8
]}

Waltzek, Thomas B. ^{[8
]}

机构：

[1] Alaska SeaLife Ctr, Seward, AK 99664 USA

[2] Monterey Bay Aquarium, Monterey, CA 93940 USA

[3] Northwest ZooPath, Monroe, WA 98272 USA

[4] Calif Anim Hlth & Food Safety, Lab Syst, Davis, CA 95617 USA

[5] Alaska Vet Pathol, Eagle River, AK 99577 USA

[6] IDEXX Labs, West Sacramento, CA 95605 USA

[7] Dept Fisheries & Oceans Canada, Winnipeg, MB R3T 2N6, Canada

[8] Univ Florida, Coll Vet Med, Gainesville, FL 32610 USA

来源：

JOURNAL OF WILDLIFE DISEASES | 2014年 / 50卷 / 03期

关键词：

Enhydra lutris; marine mammal; PCR; phylogeny; poxvirus; sea otter; skin lesion; PARAPOXVIRUS; MUTATION; SEALPOX; VIRUS; POX;

D O I：

10.7589/2013-08-217

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Small superficially ulcerated skin lesions were observed between October 2009 and September 2011 during captive care of two orphaned sea otter pups: one northern (Enhydra lutris kenyoni) in Alaska and one southern (Enhydra lutris nereis) in California. Inclusions consistent with poxviral infection were diagnosed by histopathology in both cases. Virions consistent with poxvirus virions were seen on electron microscopy in the northern sea otter, and the virus was successfully propagated in cell culture. DNA extraction, pan-chordopoxviral PCR amplification, and sequencing of the DNA-dependent DNA polymerase gene revealed that both cases were caused by a novel AT-rich poxvirus. Bayesian and maximum likelihood phylogenetic analyses found that the virus is divergent from other known poxviruses at a level consistent with a novel genus. These cases were self-limiting and did not appear to be associated with systemic illness. To our knowledge, this is the first report of a poxvirus in a mustelid species. The source of this virus, mode of transmission, zoonotic potential, and biological significance are undetermined

引用

页码：607 / 615

页数：9

共 34 条

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