Expedient Preparation of Nazlinine and a Small Library of Indole Alkaloids Using Flow Electrochemistry as an Enabling Technology

被引：75

作者：

Kabeshov, Mikhail A. ^{[1
]}

Musio, Biagia ^{[1
]}

Murray, Philip R. D. ^{[1
]}

Browne, Duncan L. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

ELECTROORGANIC CHEMISTRY; PHOTOREDOX CATALYSIS; ELECTROSYNTHESIS; CYCLOADDITIONS; CYCLIZATION; IONS; CELL;

D O I：

10.1021/ol502201d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient synthesis of the indole alkaloid nazlinine is reported. Judicious choice of flow electrochemistry as an enabling technology has permitted the rapid generation of a small library of unnatural relatives of this biologically active molecule. Furthermore, by conducting the key electrochemical Shono oxidation in a flow cell, the loading of electrolyte can be significantly reduced to 20 mol % while maintaining a stable, broadly applicable process.

引用

页码：4618 / 4621

页数：4

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